CAS: 99-77-4; Ethyl 4-Nitrobenzoate

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CAS号64-17-5 乙醇 | CAS号555-16-8 对硝基苯甲醛 | CAS号62-23-7 对硝基苯甲酸 | CAS号1906-57-6 乙基草酸钾 | CAS号586-78-7 对溴硝基苯 | CAS号636-98-6 4-硝基碘苯 | CAS号201230-82-2 carbon monoxide | CAS号80-40-0 对甲苯磺酸乙酯 | CAS号94-09-7 对氨基苯甲酸乙酯 | CAS号19213-72-0 1-乙氧甲酰咪唑 | CAS号10129-07-4 4-苯基磺酰基-苯甲酸乙酯 | CAS号50677-30-0 2-(氯甲基)-5-(4-硝基... | CAS号39695-71-1 3-苯基苯并[c]异恶唑-5-甲酸 | CAS号39695-70-0 5-ethoxycarbony... | CAS号30806-83-8 4-乙氧羰基苯基异氰酸酯 | CAS号94-32-6 对丁氨基苯甲酸乙酯 | CAS号94-24-6 丁卡因 | CAS号3847-57-2 4-硝基苯甲酸钠 | CAS号456-22-4 对氟苯甲酸 | CAS号451-46-7 4-氟苯甲酸乙酯

苯佐卡因置于sodium Perborate体系中,用 溶剂黄146 作为反应溶剂,化学反应 2.0H,以84%的收率获得产物对硝基苯甲酸乙酯
参考文献:使用过硼酸钠的官能团氧化1
标题:使用过硼酸钠的官能团氧化1
摘要:乙酸中的过硼酸钠是将苯胺氧化为硝基芳烃和将硫化物氧化为亚砜或砜的有效试剂.它也是酮二甲基hydr的氧化脱保护的极好试剂.酮的baeyer-Villiger氧化可以在三氟乙酸或乙酸/三氟乙酸混合物中用过硼酸钠进行,氢醌和某些高度取代的苯酚可以平稳地转化为醌.
DOI:10.1016/s0040-4020(01)81484-8

专利信息

专利号:US-6750335-B2
优先权日:1999-10-29
标 题 :Nucleoside derivatives with photolabile protective groups
发明人：PFLEIDERER WOLFGANG; BUEHLER SIGRID; GIEGRICH HEINER
权利人:NIGU CHEMIE GMBH
摘要:The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I) n wherein n R 1 is H, F, Cl, Br, I, or NO 2 ; R 2 is H or CN, provided that R 1 and R 2 are not simultaneously H; R 3 is H, 1-4 C alkyl, or phenyl; R 4 is H or a conventional functional group for the synthesis of oligonuleotides; R 5 is H, OH, halogen or XR 6 , where X=O or S, and R 6 is a conventional nucleotide protecting group; and B is adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl or 5-amino-4-imidazolcarboxamid-3-yl, where, if B is adenine, cytosine or guanine the primary amine functionality, optionally, carries a permanent protecting group. Furthermore, these derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.

专利号:US-6153744-A
优先权日:1996-05-20
标 题 :Nucleoside derivatives with photolabile protective groups
发明人：PFLEIDERER WOLFGANG; BUEHLER SIGRID
权利人:WOLFGANG PFLEIDERER
摘要:The invention relates to nucleo-side derivatives with photo-unstable protective groups of the general formula (I) in which R1 is H, NO2, CN, OCH3, halogen, alkyl or alkoxyalkyl with 1 to 4 C atoms, R2 is H, OCH3, R3 is H, F, Cl, Br, NO2 or an aliphatic acyl radical with 2 to 5 C atoms, R4 is H, halogen, OCH3, an alkyl radical with 1 to 4 C atoms or a possibly substituted aryl radical, R5 is H or a conventional functional group for producing oligonucleotides, R6 is H, OH, halogen or XR8, where X is O or S and R8 is a conventional protective group in nucleotide chemistry, B is adenine, cytosin, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazol carboxylic acid amid-1-yl or 5-amino-4-imidazol carboxylic acid amide-3-yl, where, if B is adenine, cytosin or guanine, the primary amino function may have a permanent protective group. These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.

专利号:EP-1112281-B1
优先权日:1998-09-08
标 题:Pteridine nucleotide analogs
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; BALIS FRANK
权利人:US GOV HEALTH & HUMAN SERV
摘要:The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.

专利号:US-5763599-A
优先权日:1994-12-16
标题:Nucleoside derivatives with photolabile protective groups
发明人：PFLEIDERER WOLFGANG; GIEGRICH HEINER
权利人:PFLEIDERER WOLFGANG
摘要:The invention relates to nucleoside derivatives having photolabile protective groups of the general formula (I) ##STR1## in which R 1 â•?H, NO 2 , CN, OCH 3 , halogen or alkyl or alkoxyalkyl having 1 to 4 C atoms n R 2 â•?H, OCH 3 n R 3 â•?H, F, Cl, Br, NO 2 n R 4 â•?H, halogen, OCH 3 , or an alkyl radical having 1 to 4 C atoms n R 5 â•?H or a usual functional group for preparing oligonucleotides n R 6 â•?H, OH, halogen or XR 8 , where Xâ•?O or S and R 8 represents a protective group usual in nucleotide chemistry, n B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl, or 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=adenine, cytosine or guanine, the primary amino function optionally exhibits a permanent protective group. n These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.

专利号:US-6716971-B1
优先权日:1998-09-08
标题:Pteridine nucleotide analogs
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; BALIS FRANK
权利人:US HEALTH
摘要:The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.

专利号:RU-2203885-C2
优先权日:2001-08-08
标题:Method of synthesis of para-aminobenzoic acid ethyl ester