Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于甲醇,Palladium On Activated Charcoal体系中,化学反应生成N-甲基-4-氯苄胺 参考文献:Catalytic Debenzylation. The Effect Of Substitution On The Strength Of The O-Benzyl And N-Benzyl Linkages1 标题:Catalytic Debenzylation. The Effect Of Substitution On The Strength Of The O-Benzyl And N-Benzyl Linkages1 摘要: Doi:10.1021/ja01250A048
专利信息
专利号:US-10125226-B2 优先权日:2013-06-05 标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils 发明人:FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR 权利人:MEXICANO INST PETROL 摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.
专利号:US-10766863-B2 优先权日:2014-11-17 标 题 :Monocarboxylate transport modulators and uses thereof 发明人:SANDANAYAKA VINCENT; WU QIONG 权利人:NIROGYONE THERAPEUTICS INC 摘要:The invention generally relates to the field of monocarboxylate transport modulators, e.g., monocarboxylate transport inhibitors, and more particularly to new substituted-quinolone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in treating, modulating, forestalling and/or reducing physiological conditions associated with monocarboxylate transport activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, obesity, diabetes, cardiovascular diseases, tissue and organ transplant rejection, and malaria.
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