CAS: 111-46-6; 2,2'-Oxybis(Ethan-1-Ol)

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二氯乙醚置于agrobacterium Tumefaciens C58 Haloalkane Dehalogenase Y109W,水体系中,用 Aq. Buffer 用作溶剂,化学反应生成二乙二醇
参考文献:独特的卤化物稳定残基对根癌农杆菌c58卤代烷脱卤酶data催化性能的影响
标题:独特的卤化物稳定残基对根癌农杆菌c58卤代烷脱卤酶data催化性能的影响
摘要:卤代烷脱卤酶催化各种氯化,溴化和碘化化合物中碳-卤键的水解.这些酶具有一对保守的卤化物稳定残基,这些残基对底物结合以及通过氢键稳定过渡态和卤化物离子产物起重要作用.在所有先前已知的卤代烷脱卤酶中,这些残基是一对色氨酸或一个色氨酸-天冬酰胺对.根癌农杆菌c58(ec 3.8.1.5)中新分离的卤代烷脱卤酶data具有独特的卤化物稳定酪氨酸残基y109,代替了常规色氨酸.创建了具有y109W突变的data变体,并使用光谱学和稳态前动力学实验研究了该突变对酶的结构和催化性能的影响.使用量子力学和分子动力学计算来获得对野生型和突变体活性位点内氢键模式的详细分析,以及随着反应的进行对配体的稳定化的详细分析.荧光猝灭实验表明,用色氨酸替代酪氨酸可使卤化物结合提高3.7倍,这可能是由于引入了额外的氢键所致.动力学分析表明,该突变影响了酶的底物特异性,并将其对选定的卤代底物的k0.5降低了2-4倍,而不影
Doi:10.1111/febs.12238

专利信息

专利号:WO-2009018504-A1
优先权日:2007-08-01
标题 :Process for the synthesis of diaminopyridine and related compounds
发明人：RITTER JOACHIM C
权利人:DU PONT; RITTER JOACHIM C
摘要:A process is provided for the synthesis of a diaminopyridine, such as 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-8084569-B2
优先权日:2006-12-21
标 题 :Process for the synthesis of diaminopyridines from glutarimidines
发明人：MINTER AARON; STOKES BERLIN
权利人:MINTER AARON; STOKES BERLIN; DU PONT
摘要:A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.

专利号:US-2021130543-A1
优先权日:2019-10-30
标 题:Synthesis of cyanurate and multifunctional alcohol-based polyether acrylate for uv curable materials
发明人：YUAN ZHONGSHUN; XU CHUNBAO; WU WEI
权利人:YUAN ZHONGSHUN; XU CHUNBAO; WU WEI
摘要:Polyether (meth)acrylates based on cyanuric acid or substituted cyanuric acid and multifunctional alcohol, which optionally include triethanolamine units, have wide applications in UV curable adhesives, coatings, inks, sealants, paints or 3D printing. These polyether acrylates have rigid cyanurate structure endowing the material with extra strength and thermal stability. Furthermore, triethanolamine unit, when present, endows the material with anti-oxygen inhibition property in UV curing process. These polyether (meth)acrylates have low viscosity and high reactivity towards UV curing. The cured resins have high resilience and strength. The process of making the polyether (meth)acrylates includes the synthesis of trifunctional polyether polyols through controlled polymerization of propylene oxide using multifunctional alcohol (such as glycerol and sucrose), cyanuric acid or substituted cyanuric acid, and optionally triethanolamine, in the presence of a catalyst, followed by the synthesis of polyether (meth)acrylates through transesterification or through direct esterification of the trifunctional polyether polyols.

专利号:US-8415510-B2
优先权日:2008-02-28
标题 :Synthesis of a PEG-6 moiety from commercial low-cost chemicals
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.

专利号:US-8536375-B2
优先权日:2008-12-22
标题:Synthesis of obtaining modified polyethylene glycol intermediates
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.