CAS: 117391-50-1; Dl-3-Amino-3-(3-Bromophenyl)Propionic Acid

相似化合物

275826-35-2 788153-27-5 501015-16-3

上下游产品

m-bromobenzoic aldehyde malonic acid3-(3-bromophenyl)-3-(2,2,2-trifluoroacetamido)-propanoic acid 3-(3-Bromo-phenyl)-3-(2,2,2-trifluoro-acetylamino)-propionyl chloride 3-amino-3-(3-bromo-phenyl)-propionic acid methyl ester 3-Brom°Cinnamic acid

间溴苯甲醛,丙二酸置于甲酸铵体系中,用 乙醇 用作溶剂,化学反应 4.0H,以78%的收率获得3-氨基-3-(3-溴苯基)丙酸
参考文献:苯丙氨酸氨解酶和氨基酸变位酶生物催化剂的组合,对芳香族β-氨基酸的动力学拆分
标题:苯丙氨酸氨解酶和氨基酸变位酶生物催化剂的组合,对芳香族β-氨基酸的动力学拆分
摘要:已经证明了使用苯丙氨酸氨基变位酶和氨裂合酶(pam和pal)酶制备(R)-β-芳基丙氨酸的酶促策略.具有海马链霉菌(encp)和芽孢杆菌(bacillus Sp.)选择性(S)选择性的候选pam .(pabh)通过使用充分研究的模板序列进行序列分析来鉴定.新发现的pabh可能与首次提出的幽门螺杆菌样二级代谢产物的生物合成有关,并在许多情况下显示出更好的β-裂合酶活性.尽管如此,Encp的较高的转化率具有严格α-裂解酶合成的方法从多变鱼腥藻(avpal)被认为是更合适的,它允许五种外消旋底物的动力学拆分以及制备规模的对映体过量> 98%(R)的反应.这项工作代表了对现有生物催化策略的一种改进和对映体互补的方法,它允许简单的产品分离和模块化的伸缩组合,以及使用非手性醛作为原料的先前化学步骤.
Doi:10.1002/adsc.201600894

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:US-11091522-B2
优先权日:2018-07-23
标题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.