CAS: 1299607-55-8; 1-Boc-5-Bromo-1H-Pyrazolo[3,4-B]Pyridine

相似化合物

1449693-24-6 875781-17-2 887115-56-2

上下游产品

1-Boc-5-溴-3-碘-1H-吡唑并[3,4-B]吡啶 Tert-Butyl 5-Bromo-3-Iodo-1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate 916326-31-3

3-碘-1H-吡唑并[3,4-B]吡啶置于4-二甲氨基吡啶,溴,叔丁基锂,溶剂黄146,三乙胺体系中,用 四氢呋喃 用作溶剂,化学反应 12.0H,反应生成1-Boc-5-溴-1H-吡唑并[3,4-B]吡啶
参考文献:Synthesis Of 3-(1H-Benzimidazol-2-yl)-5-Isoquinolin-4-Ylpyrazolo[1,2-B]Pyridine,A Potent Cyclin Dependent Kinase 1 (Cdk1) Inhibitor
标题:Synthesis Of 3-(1H-Benzimidazol-2-yl)-5-Isoquinolin-4-Ylpyrazolo[1,2-B]Pyridine,A Potent Cyclin Dependent Kinase 1 (Cdk1) Inhibitor
摘要:The Novel Compound 3-(1H-Benzimidazol-2-yl)-5-Isoquinolin-4-Ylpyrazolo[1,2-B]Pyridine Was Discovered To Be A Potent Cdk1 Inhibitor. Described Here Is The Chemistry For Its Synthesis,Including Pd(II) Catalyzed Stille Coupling Reaction And Sulfur(0) Induced Benzimidazole Formation. Its Effects On Vegfr-2 Kinase Activity And Tumour Cell Proliferation Are Also Described.
Doi:10.1016/j.Bmcl.2006.12.031