CAS: 1462-86-8; 3-Aminopicolinic Acid

相似化合物

569687-82-7 27507-15-9 42242-11-5

上下游产品

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2,3-吡啶二酰亚胺置于sodium Hydroxide,Sodium Hypobromide体系中,化学反应 2.0H,以10%的收率获得3-氨基吡啶-2-羧酸
参考文献:3-芳基-4-羟基喹啉-2(1H)-作为nmda /甘氨酸部位拮抗剂的5-,6-,7-和8-氮杂类似物的合成和sar.
标题:3-芳基-4-羟基喹啉-2(1H)-作为nmda /甘氨酸部位拮抗剂的5-,6-,7-和8-氮杂类似物的合成和sar.
摘要:合成了3-芳基-4-羟基喹啉-2(1H)-One的一系列5-,6-,7-和8-氮杂类似物,并测定为nmda /甘氨酸受体拮抗剂.这些拮抗剂的体外效能是通过在大鼠大脑皮膜中置换甘氨酸位点放射性配体[[(3)h] 5,7-Dicholorokynurenic酸([(3)h] Dcka)确定的.还使用表达克隆的nmda受体(nr)1A / 2C亚基的非洲爪蟾卵母细胞中的电生理测定法测试了所选化合物的功能拮抗作用.在研究的5,6,7,8氮杂-3-芳基-4-羟基喹啉2(1H)-中,5-氮杂7-氯-4-羟基-3-(3-苯氧基苯基) )quinolin-2-(1H)-One(13I)是最有效的拮抗剂,在[(3)h] Dcka结合中的ic(50)值为110 Nm,在电生理学中的k(b)为11 Nm分析.
Doi:10.1016/s0968-0896(01)00115-8

专利信息

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:US-3950160-A
优先权日:1972-09-27
标题:Inhibiting the growth of weeds with 2-substituted pyrdidopyimidines and salts thereof
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:US-8471006-B2
优先权日:2003-10-31
标题:Coupling agents for peptide synthesis
发明人：CARPINO LOUIS A; XIA JUSONG; ZHANG CHONGWU; SFERDEAN CALIN DAN
权利人:CARPINO LOUIS A; XIA JUSONG; ZHANG CHONGWU; SFERDEAN CALIN DAN; UNIV MASSACHUSETTS
摘要:The present invention is directed to compounds of the formula: n nor salts thereof or N-oxides and their use in peptide synthesis.

专利号:US-3962264-A
优先权日:1972-09-27
标 题:Process for making 2-amino nicotinonitrile
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:CN-101575712-A
优先权日:2009-04-30
标 题 :Method for electrolytic synthesis of 4-amino-3,6-dichloropyridine-2-carboxylic acid

专利号:US-3917624-A
优先权日:1972-09-27
标题:Process for producing 2-amino-nicotinonitrile intermediates
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.