CAS: 14984-68-0; 1-(2-((4-Chlorophenyl)(Phenyl)Methoxy)Ethyl)Piperidine Hydrochloride

上下游产品

1-piperidinoethanol 1-chloro-4-(chloro(phenyl)methyl)benzene 2-(piperidin-4-yl)ethyl chloride (4-chlorophenyl)phenylmethanol

N-羟乙基哌啶,4-氯二苯氯甲烷置于三乙胺,盐酸体系中,用 二氯甲烷,醋酸异丙酯 用作溶剂,化学反应 4.0H,以91.2%的收率获得咳平 盐酸盐
参考文献:一种盐酸氯哌丁的制备方法
标题:一种盐酸氯哌丁的制备方法
摘要:一种盐酸氯哌丁的制备方法,将式(ⅵ)和式(ⅲ)置于溶剂或无溶剂,经过缩合或醚化反应,分离得到1‑[2‑[(4‑氯‑α苯基苄基)氧]乙基]哌啶(ⅱ);1‑[2‑[(4‑氯‑α苯基苄基)氧]乙基]哌啶在溶剂中与氯化氢或盐酸成盐得到盐酸氯哌丁.本发明工艺条件温和,操作方便,简单,适用于大规模工业化生产,生产得到的目标产品纯度达到99.7%以上,且单个杂质小于0.1%.

专利信息

专利号:US-9708317-B2
优先权日:2013-11-25
标 题 :Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
发明人：ZAMBON ALFONSO; NICULESCU-DUVAZ DAN; CHUBB RICHARD; SPRINGER CAROLINE JOY
权利人:CANCER RES TECH LTD; INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); OXY SCIENT LTD; THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
摘要:The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

专利号:US-8835477-B2
优先权日:2009-10-06
标题 :Method for the synthesis of 2-thiohistidine and the like
发明人：ERDELMEIER IRÈNE; DAUNAY SYLVAIN
权利人:ERDELMEIER IRÈNE; DAUNAY SYLVAIN; TETRAHEDRON
摘要:Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.

专利号:WO-2023044581-A1
优先权日:2021-09-24
标题 :Flow synthesis of porous collagen microparticles for versatile tissue engineering applications
发明人：SINGH SUSHANT; SAMIEI EHSAN; GUENTHER AXEL; VERES TEODOR
权利人:GOVERNING COUNCIL UNIV TORONTO; NAT RES COUNCIL CANADA; SINGH SUSHANT
摘要:A microfluidic flow synthesis method for collagen-based microparticles. Macro-porous fibrillar microparticles of pure collagen and composite collagen-GAG were formed, where the particle size and porosity were controlled by the flow synthesis parameters such as precursor flow rates. Using human dermal fibroblasts (hDFB) and umbilical cord derives mesenchymal stem cells (ucMSC), the capacity of the presented collagen and collagen-GAG microparticles to serve as cell culture substrates has been shown, to enable casting of tissues, forming spheroids, and as shear-thinning bioinks for bioprinting. At high packing densities, jammed collagen-based microparticles along with cells constitute a shear-thinning bioink for extrusion bioprinting applications. Bioprinted constructs exhibit a high porosity matrix due to the space between the microparticles, facilitating macromolecular transport, and cell proliferation and migration.

专利号:US-6013796-A
优先权日:1996-07-26
标 题:Preparation of naltrexone from codeine and 3-benzylmorphine
发明人：HUANG BAO-SHAN; LU YANSONG; JI BEN-YI; CHRISTODOULOU ARIS P
权利人:PENICK CORP
摘要:For the synthesis of 3-methylnaltrexone from codeine in this invention, codeine is converted to 6-acetylcodeine, which is N-demethylated to 6-acetylcodeine hydrochloride, followed by alkylating the nitrogen to form 17-cyclopropylmethylnorcodeine. The latter is oxidized to 17-cyclopropylmethylnorcodeinone. For the synthesis of naltrexone from morphine in this invention, morphine is converted to 3-benzylnormorphine as described above in the synthesis of noroxymorphone. 3-Benzylnormorphine is reacted with cyclopropylmethyl halide to produce 3-benzyl-17cyclopropylmethylnormorphine, a novel compound, which is oxidized to 3-benzyl-17-cyclopropylmethyl-normorphinone, a novel compound, by Swern oxidation.

专利号:US-6136452-A
优先权日:1998-02-27
标 题:Centrifugal synthesis and processing of functionally graded materials
发明人：MUNIR ZUHAIR A; LAI WEI NONG; RISBUD SUBHASH H; MCCOY BENJAMIN J
权利人:UNIV CALIFORNIA
摘要:A method through which we can synthesize Functionally Graded Materials (FGM). Such materials are made so that their composition changes gradually from one point to another, such as in the example of gradient index (GRIN) optical components. A novel aspect of our method is the imposition of a centrifugal force during the combustion synthesis of composite materials for structural, optical, or electronic applications, with the result that the composition and the particle size of the metallic (or ceramic) component changes continuously and across the thickness of the product. We have prepared such FGM as ZrO 2 +Ni, ZrO 2 +Cu and Al 2 O 3 +Cu.

专利号:US-10640508-B2
优先权日:2017-10-13
标 题 :Diazene directed modular synthesis of compounds with quaternary carbon centers
发明人：MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are directed to the preparation of compounds of Formula (I), or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, from compounds of Formula (II): n nwherein R 1 -R 5 and q are as defined independently for each occurrence herein. A wide variety of compounds can be accessed in this manner, including oligocyclotryptamines, where the stereochemistry of each subunit is beneficially secured before fragment coupling.