CAS: 175291-56-2; (2S,3R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(((Benzyloxy)(Hydroxy)Phosphoryl)Oxy)Butanoic Acid

相似化合物

937171-63-6 158171-14-3 146306-75-4

上下游产品

(2S,3R)-3-[Benzyloxy-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 2-oxo-2-phenyl-ethyl ester Fm°C-Thr-OH benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite N-(9-fluorenylmethyloxycarbonyl)-L-threonine phenacylester67H102N19O19PS3C67H102N19O19PS3 184B-91-1

专利信息

专利号:US-10047122-B2
优先权日:2013-03-14
标 题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：QIAN WENJIAN; PARK JUNG EUN; LAI CHRISTOPHER C; KELLEY JAMES A; LEE KYUNG S; BURKE JR TERRENCE R
权利人:THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.