CAS: 455-19-6; 1-Formyl-4-Trifluoromethylbenzene

上下游产品

CAS号201230-82-2 carbon monoxide | CAS号402-43-7 对溴三氟甲苯 | CAS号455-13-0 4-碘三氟甲苯 | CAS号349-95-1 4-(三氟甲基)苄醇 | CAS号146397-87-7 4-(三氟甲基)苯基三氟甲磺酸酯 | CAS号1071965-81-5 [Pd(Br)(p-CF3C6... | CAS号66046-34-2 N-[[4-(trifluor... | CAS号395-35-7 4-(三氟甲基)扁桃酸 | CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号1027382-23-5 tert-butyldimet... | CAS号105763-99-3 3-[[4-(trifluor... | CAS号101466-85-7 3-(4-(三氟甲基)苯基)丙烯酸乙酯 | CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号110283-79-9 CI-966 | CAS号32857-62-8 4-(三氟甲基)苯乙酸 | CAS号34898-30-1 2-[4-(三氟甲基)苯基]-1H-咪唑 | CAS号35852-58-5 3-氯-4-羟基三氟甲苯 | CAS号349-95-1 4-(三氟甲基)苄醇 | CAS号3300-51-4 对三氟甲基苄胺 | CAS号98-86-2 苯乙酮

1-溴-三氟对二甲苯置于乌洛托品体系中,用 氯仿 作为反应溶剂,化学反应 1.0H,反应生成 对三氟甲基苯甲醛
参考文献:Effects Of Substituents And Medium On Acidity Of α,α-Bis(Butylsulfonyl)Toluenes
标题:Effects Of Substituents And Medium On Acidity Of α,α-Bis(Butylsulfonyl)Toluenes
摘要:已准备了七种替代的α,α-双(丁基磺酰基)甲苯和三种2-芳基-1,1,3,3-四氧杂环戊二酮的样品,并测量了它们的1H NMR,Ir和ms光谱.通过在二甲基亚砜,二甲基甲酰胺和二甲基亚砜与水80%(体积比)混合物中进行电位滴定,确定了替代的α,α-双(丁基磺酰基)甲苯的pkha值.利用yukawa-Tsuno关系(参数r=0.43-0.49)解释了结果,并通过潜在变量方法(共轭偏差法)将其与类似的n-酸和o-酸进行了分类.
DOI:10.1135/cccc19940391

专利信息

专利号:US-9242925-B2
优先权日:2011-08-29
标题:Versatile and stereospecific synthesis of γ,δ-unsaturated amino acids by Wittig reaction
发明人：JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE
权利人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE; CENTRE NAT RECH SCIENT; UNIV BOURGOGNE
摘要:The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). n n n n n n n n n n n n Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-9085550-B2
优先权日:2005-01-21
标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
发明人：FORMAN BARRY; YU DONNA
权利人:FORMAN BARRY; YU DONNA; HOPE CITY
摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

专利号:US-9597327-B2
优先权日:2005-05-25
标 题:Synthesis of (R)-N-methylnaltrexone
发明人：DOSHAN HAROLD D; PEREZ JULIO
权利人:PROGENICS PHARM INC
摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.