CAS: 51376-06-8; 5-Bromobenzo[c][1,2,5]Oxadiazole

上下游产品

CAS号36387-84-5 5-溴-2,1,3-苯并恶唑氮氧化物 | CAS号41153-83-7 6-溴苯并[c][1,2,5]... | CAS号875-51-4 4-溴-2-硝基苯胺 | CAS号88-74-4 2-硝基苯胺 | CAS号847672-84-8 4-bromo-2-nitro... | CAS号73686-38-1 4-bromo-[1,2]be... | CAS号54286-62-3 苯并[c][1,2,5]噁二唑-5-腈 | CAS号426268-09-9 苯并[c][1,2,5]恶二唑... | CAS号426268-06-6 4-[8-(2,1,3-ben... | CAS号54286-60-1 2,1,3-benzoxadi...

5-溴-2-硝基苯胺置于sodium Hypochlorite,Potassium Hydroxide,亚磷酸三乙酯体系中,用 四氢呋喃,乙醇,水 作为反应溶剂,化学反应 7.0H,反应生成 5-溴-2,1,3-苯并恶唑
参考文献:铜催化苯并恶二唑与二芳基碘鎓盐的π-核演化,用于区域选择性合成吩嗪骨架.
标题:铜催化苯并恶二唑与二芳基碘鎓盐的π-核演化,用于区域选择性合成吩嗪骨架.
摘要:由苯并恶二唑和二芳基碘鎓盐实现了铜催化的吩嗪n-氧化物的区域选择性合成.该过程通过苯并恶二唑与二芳基碘鎓盐的亲电芳基化反应开始,然后进行苯并环化反应.容易将原位n-氧化物进一步还原为吩嗪支架并偏离有机荧光材料.
DOI:10.1021/acs.Orglett.8B01748

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:RU-2194035-C2
优先权日:1996-03-08
标题:Triaryl compounds, method of their synthesis, pharmaceutical composition based on thereof, method of treatment and intermediates substances