CAS: 5497-76-7; H-Pro-Otbu.Hcl

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2812-46-6 184719-80-0 90071-62-8

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CAS号115-11-7 2-甲基丙烯 | CAS号147-85-3 脯氨酸 | CAS号91237-84-2 (2S)-5-氧代-1,2-吡... | CAS号2812-46-6 L-脯氨酸叔丁基酯 | CAS号2812-46-6 L-脯氨酸叔丁基酯

N-Boc-Proline Tert-Butyl Ester置于盐酸体系中,用 乙酸乙酯 作为反应溶剂,化学反应生成 L-脯氨酸叔丁酯盐酸盐
参考文献:Selective Removal Of An N-Boc Protecting Group In The Presence Of A Tert-Butyl Ester And Other Acid-Sensitive Groups
标题:Selective Removal Of An N-Boc Protecting Group In The Presence Of A Tert-Butyl Ester And Other Acid-Sensitive Groups
摘要:
DOI:10.1021/jo00090A045

专利信息

专利号:US-7435791-B2
优先权日:2001-07-19
标题:Process for rapid solution synthesis of peptides
发明人：EGGEN IVO FRANCI; TEN KORTENAAR PAULUS BERNARDUS; HAASNOOT CORNELIS ALBERT GRUSON
权利人:ORGANON NV
摘要:The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d):n (a) a coupling step, using an excess of an activated carboxylic component to acylate an amino component, (b) a quenching step in which a scavenger is used to remove residual activated carboxylic functions, wherein the scavenger may also be used for deprotection of the growing peptide, (c) one or more aqueous extractions and optionally, (d) a separate deprotection step, followed by one or more aqueous extractions, characterised in that the process comprises at least one step (b), referred to as step (b′), in which an amine or a thiol comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions. nn During the process of this invention the growing peptide need not be isolated until the final peptide sequence has been obtained. n This highly efficient process is useful for the production of oligo- and polypeptides of high purity.

专利号:EP-0598899-B1
优先权日:1992-06-16
标 题 :Liquid phase synthesis of peptides and peptide derivatives
发明人：SIWRUCK GARY A; EYNON JOHN S
权利人:KINERTON LTD
摘要:A liquid phase peptide synthetic method which uses (1) Fmoc as the protecting group for the non-side chain amino functionality, (2) ammonia, a primary or secondary amine to remove the Fmoc protecting group, and (3) substituted carbodiimide as the coupling agent for the C to N synthesis of peptides or peptide derivatives in a proper organic solvent.

专利号:US-5516891-A
优先权日:1992-06-16
标题:Liquid phase synthesis of peptides and peptide derivatives
发明人：SIWRUK GARY A; EYNON JOHN S
权利人:KINERTON LTD
摘要:PCT No. PCT/US93/05783 Sec. 371 Date May 25, 1994 Sec. 102(e) Date May 25, 1994 PCT Filed Jun. 16, 1993 PCT Pub. No. WO93/25571 PCT Pub. Date Dec. 23, 1993.A liquid phase peptide synthetic method which uses (1) Fmoc as the protecting group for the non-side chain amino functionality, (2) ammonia, a primary or secondary amine to remove the Fmoc protecting group, and (3) substituted carbodiimide as the coupling agent for the C to N synthesis of peptides or peptide derivatives in a proper organic solvent.

专利号:US-6797820-B2
优先权日:1999-12-17
标 题:Succinate compounds, compositions and methods of use and preparation
发明人：PATEL DINESH; JACOBS JEFFREY W; JAIN RAKESH; NI ZHI-JIE; YUAN ZHENGYU
权利人:VICURON PHARM INC
摘要:Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

专利号:WO-9325571-A1
优先权日:1992-06-16
标 题:Liquid phase synthesis of peptides and peptide derivatives

专利号:CN-115043864-A
优先权日:2022-06-30
标 题:Process for the synthesis of intermediates and intermediates