CAS: 56553-60-7; Sodium Triacetoxyborohydride

上下游产品

CAS号64-19-7 冰醋酸 | CAS号16940-66-2 硼氢化钠 | CAS号1063733-41-4 N-(2,4-二甲氧基苄基)-... | CAS号229007-09-4 4-[N-甲基-N-(四氢-2... | CAS号198823-22-2 3-(1-苄基哌啶-4-基氨基... | CAS号1273-86-5 羟甲基二茂铁 | CAS号1271-86-9 N,N-二甲基二茂铁甲胺 | CAS号169943-40-2 N-甲基-4-苯氧基苄胺 | CAS号2439-56-7 环戊基甲基胺 | CAS号1146946-20-4 3-(1,3-Benzoxaz... | CAS号42870-65-5 N-环庚基甲胺 | CAS号38043-08-2 N-(4-Fluorophen...

溶剂黄146置于sodium Tetrahydroborate体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 三乙酰氧基硼氢化钠
参考文献:利特嗪 B 的全合成
标题:利特嗪 B 的全合成
摘要:报道了细胞毒性生物碱利特嗪 B 的首次全合成.该合成对两个类固醇亚基采用统一的方法,采用钛介导的炔丙基化反应来实现与常见前体的不同.其他关键步骤包括金催化的环异构化,安装螺缩酮和后期 C-H 氧化以掺入 C7' 醇.
DOI:10.1021/jacs.1C01372

专利信息

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-2024294462-A1
优先权日:2023-02-15
标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate
发明人：SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD
权利人:NANOVATION THERAPEUTICS INC
摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.

专利号:US-9506095-B2
优先权日:2012-02-09
标 题:Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application in the synthesis of ivabradine and salts thereof
发明人：PEDRAGOSA-MOREAU SANDRINE; LEFOULON FRANÇOIS
权利人:SERVIER LAB; LES LABORATORIES SERVIER
摘要:Process for the enzymatic synthesis of the compound of formula (I): n nwherein R 1 represents a hydrogen atom or an alkyl group.n n Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-2019047933-A1
优先权日:2016-03-15
标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid
发明人：ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÃœCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám
权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC
摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-11639349-B2
优先权日:2020-05-28
标题:Stereoselective synthesis of intermediate for preparation of heterocyclic compound
发明人：CHEN WEN-CHANG; HSU HAN-PEI; CHOU SHAN-YEN; CHUANG SHIH-CHIEH; YEN CHI-FENG
权利人:TAI GEN BIOTECHNOLOGY CO LTD; TAIGEN BIOPHARMACEUTICALS CO BEIJING LTD; TAIGEN BIOTECHNOLOGY CO LTD
摘要:Provided is a stereoselective synthesis of an intermediate for the preparation of the heterocyclic derivative as a Cap-dependent endonuclease inhibitor. The synthesis process has the advantages of simple operation, higher yield and relatively controllable steroselectivity, such that it is suitable for large-scale production.