CAS: 64465-53-8; 4-Fluoro-3-Methoxyaniline

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CAS号454-16-0 2-氟-5-硝基苯甲醚 | CAS号3863-11-4 3,4-二氟苯胺 | CAS号3866-16-8 3-Azidoanisole | CAS号536-90-3 间氨基苯甲醚 | CAS号321-28-8 2-氟苯甲醚 | CAS号103291-07-2 2-氟-5-溴苯甲醚 | CAS号100367-48-4 5-氨基-2-氟苯酚 | CAS号773855-64-4 1-氟-4-碘-2-甲氧基苯 | CAS号887266-97-9 4-氟-3-甲氧基苯-1-磺酰氯

专利信息

专利号:US-2024182421-A1
优先权日:2021-03-19
标题 :Synthesis of endochin-like quinolones
发明人：RISCOE MICHAEL K; NILSEN AARON; JIN HAIHONG; POU SOVITJ; WINTER ROLF W; DODEAN ROZALIA ANA; LIEBMAN KATHERINE M
权利人:UNIV OREGON HEALTH & SCIENCE; US GOV VETERANS AFFAIRS
摘要:Described herein are new synthetic routes for production of Endochin-Like Quinolone (ELQ) compounds. Synthetic routes to 3-substituted 4(1H)-quinolones are presented that are amenable to industrial scale preparation. One herein presented approach is relatively short, does not require palladium, and involves no chromatographic separation. A second herein presented approach is similarly relatively short, does not require palladium, involves no chromatographic separation, and also avoids high vacuum distillation. Additionally, both approaches require no protecting group chemistry because the insoluble 4(1H)-quinolone is not formed until the final reaction step.

专利号:US-2022281888-A1
优先权日:2019-09-25
标题:Bicyclic carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT; GORECZNY GREGORY
权利人:NIROGY THERAPEUTICS INC
摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:WO-2022197979-A1
优先权日:2021-03-19
标题:Synthesis of endochin-like quinolones

专利号:EP-4308109-A1
优先权日:2021-03-19
标 题:Synthesis of endochin-like quinolones

专利号:CN-117042768-A
优先权日:2021-03-19
标题:Synthesis of doxine-like quinolones

专利号:WO-2024121199-A1
优先权日:2022-12-07
标 题 :Processes for making endochin-like quinolones from alkyl 3-(3- alkoxyphenyl)amino)-2-(4-(4-alkoxy)phenoxy)phenyl)but-2-enoate
发明人：VEIT STEPHAN; CHASSAING CHRISTOPHE
权利人:INTERVET INT BV; INTERVET INC
摘要:A new scalable synthesis for the preparation of endochin-like quinolone compounds of Formula (I), wherein R is H, Cl or F, preferably F and R2 is C1-C2 alkyl, preferably C1 alkyl, wherein the synthesis comprises a process for preparing a compound of Formula (4) wherein R1 is C1-C2 alkyl, preferably C1 alkyl.