CAS: 78573-45-2; 3-(3-(Trifluoromethyl)Phenyl)Propan-1-Ol

上下游产品

CAS号65126-85-4 3-(3-(三氟甲基)苯基)p... | CAS号294856-02-3 Methyl 3-(3-(tr... | CAS号585-50-2 3-(3-三氟甲基苯基)丙酸 | CAS号64189-17-9 3-[3-(trifluoro... | CAS号113048-69-4 (E)-3-(3-三氟甲基苯基... | CAS号713-71-3 2-[3-(trifluoro... | CAS号70311-33-0 间三氟甲基苯丙酸乙酯 | CAS号262268-58-6 间三氟甲基肉桂醛 | CAS号21172-41-8 3-(3-三氟甲基苯基)丙醛 | CAS号779-89-5 间三氟甲基肉桂酸 | CAS号364782-34-3 盐酸西那卡塞 | CAS号129254-76-8 1-(3-溴丙基)-3-(三氟甲基)苯 | CAS号226256-56-0 西那卡塞 | CAS号21172-41-8 3-(3-三氟甲基苯基)丙醛 | CAS号82258-76-2 1-(3-氯丙基)-3-(三氟甲基)苯

1-(3-(Trifluoromethyl)Phenyl)Prop-2-En-1-Ol置于palladium On Activated Charcoal 吡啶,Titanium(Iv) Isopropylate,叔丁基过氧化氢,Lithium Aluminium Tetrahydride,L-(+)-酒石酸二乙酯,硫酸,氢气体系中,用 乙醚,乙醇,二氯甲烷 作为反应溶剂,化学反应 68.5H,反应生成 3-(3-三氟甲基苯基)丙醇
参考文献:无锐环氧化法不对称合成(S)-芬氟拉明
标题:无锐环氧化法不对称合成(S)-芬氟拉明
摘要:我们描述了(S)芬氟拉明的一种合成及其前体(R)-和(S)-1-(间三氟甲基苯基)丙烷-2-醇的几种合成方法.它们是由伯烯丙基醇5的不对称环氧化和仲烯丙基醇6的不对称环氧化的动力学拆分获得的.
DOI:10.1016/s0040-4020(01)80743-2

专利信息

专利号:US-8614354-B2
优先权日:2008-06-18
标题 :Process for the synthesis of cinacalcet hydrochloride
发明人：FERRARI MASSIMO; GHEZZI MARCELLO; BONALDI MATTEO
权利人:FERRARI MASSIMO; GHEZZI MARCELLO; BONALDI MATTEO; ERREGIERRE SPA
摘要:There is described a process for the preparation of cinacalcet hydrochloride (I) which includes the steps of: a) reacting (R)-(+)-1-(1-naphthyl)ethylamine (II) with 3-[3-(trifluoromethyl)phenyl]propenaldehyde (III) to afford the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[1-(1-naphthyl)ethylamine (IV); b) reducing the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[-1-(1-naphthyl)ethylamine (IV) with a sequential addition of:—a solution of sodium borohydride, methanol and a base,—oxalic acid and—a base to obtain (R)—N-[3-[3-(tifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) by passing through the precipitation of the oxalate salt of compound (V) after the addition of oxalic acid; c) hydrogenating (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) thus obtaining (R)—N-(3-(3-(trifluoromethyl)phenyl]propyl]-1-(1-naphthyl)ethylamine cinacalcet base (VI), which is retaken in ethyl acetate; and d) treating the solution of cinacalcet base (VI) in ethyl acetate with hydrochloric acid to afford cinacalcet hydrochloride (I).

专利号:US-2010267988-A1
优先权日:2006-06-08
标 题:Processes for preparing intermediate compounds useful for the preparation of cinacalcet
发明人：SZEKERES TIBOR; REPASI JOZSEF; SZABO ANDRAS; MANGION BERNARDINO
权利人:MEDICHEM SA
摘要:The invention relates, in general, to an improved process for preparing compounds (e.g., 3-(3-trifluoromethylphenyl)propanal (Compound III, below)), which are key intermediates for the synthesis of cinacalcet, its salts and/or solvates thereof, as well as the use of such compounds prepared by such process for the preparation of cinacalcet and/or its salts or solvates.

专利号:EP-1990333-A1
优先权日:2007-05-11
标题 :Process for the preparation of cinacalcet hydrochloride
权利人:SANDOZ AG
摘要:The present invention relates to a process for the preparation of cinacalcet hydrochloride which is industrially feasible and commercially viable. The synthesis of cinacalcet hydrochloride is carried out by the condensation of 3-trifluromethylphenyl propionic acid with R-(+)-1-(lnaphthyl)ethylamine.

专利号:US-2008319229-A1
优先权日:2007-06-22
标题 :process for the preparation of cinacalcet
发明人：ALLEGRINI PIETRO; ATTOLINO EMANUELE
权利人:DIPHARMA FRANCIS SRL
摘要:The invention provides a novel process for the preparation of a compound of formula (I) n n n n n n n n n n n n which includes the reduction of a compound of formula (II) or a salt thereof, in the presence of a catalyst, n n n n n n n n n n n n n n n n and novel intermediates useful for its synthesis.

专利号:US-2011105799-A1
优先权日:2008-06-18
标 题 :process for the synthesis of cinacalcet hydrochloride

专利号:EP-2321256-A1
优先权日:2008-06-18
标 题:A process for the synthesis of cinacalcet hydrochloride