CAS: 104830-06-0; 2-Amino-3-Iodopyridine

相似化合物

54231-34-4 23597-15-1 20511-12-0

上下游产品

CAS号113975-31-8 N-(3-碘吡啶-2-基)棕榈酰胺 | CAS号13534-99-1 2-氨基-3-溴吡啶 | CAS号78607-36-0 2-氯-3-碘吡啶 | CAS号113975-22-7 2-氟-3-碘吡啶 | CAS号504-29-0 2-氨基吡啶 | CAS号6298-19-7 2-氯-3-氨基吡啶 | CAS号372-48-5 2-氟吡啶 | CAS号104830-07-1 3-(4-氨基吡啶-3-基)丙烯酸乙酯 | CAS号381233-96-1 2-氨基-3-碘-5-溴吡啶 | CAS号905966-34-9 5-溴-3-((三甲基甲硅烷基... | CAS号15936-09-1 1,8-萘啶-2(8h)-酮 | CAS号67346-74-1 3-乙炔吡啶-2-胺 | CAS号388565-59-1 1,8-萘啶-2-羧酸乙酯 | CAS号53439-81-9 苯并[c][1,8]萘啶-6(5h)-酮

2-氯-3-碘吡啶置于盐酸乙脒,Sodium Hydroxide体系中,用 水,二甲基亚砜 用作溶剂,化学反应 24.0H,以23%的收率获得2-氨基-3-碘吡啶
参考文献:从2-氟吡啶和乙酰胺盐酸盐到2-氨基吡啶衍生物的无过渡金属访问
标题:从2-氟吡啶和乙酰胺盐酸盐到2-氨基吡啶衍生物的无过渡金属访问
摘要:在无催化剂的条件下,已经开发了一种通过2-氟吡啶和乙am盐酸盐的亲核取代和水解来合成2-氨基吡啶衍生物的有效方法.该胺化反应使用廉价的乙am盐酸盐作为氨源,具有收率高,化学选择性高,底物适应性广的优点.结果表明,其他含有氟取代基的n-杂环也可以通过这些反应条件完成反应并产生目标产物.
Doi:10.1039/c8Ob02129E

专利信息

专利号:US-2006183758-A1
优先权日:2005-02-17
标 题:Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
发明人：BEARD CHARLES D; LEE VING J; WHITTLE C E
权利人:CB RES AND DEV INC
摘要:Methods of synthesis of intermediates that are useful as bioisosteres of the indole, benzofuran and benzothiophene scaffold are disclosed.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:CN-104262242-B
优先权日:2014-09-22
标题 :Synthesis of 3,5-diiodo-4-aminopyridine by in situ generation of iodo reagent

专利号:WO-2008022467-A1
优先权日:2006-08-25
标 题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).