CAS: 14143-32-9; 4-Chloro-3-Ethylphenol

该化合物是一种有机化合物,其特征是存在一个氯基组和一个附于苯球圈的乙基组;其分子结构包括一个在副位置(4个位置)与氯原子的苯酚混合物,以及一个在元位置(3个位置);该化合物一般无色可粉黄黄色液体或固体,视其纯度和形态而定;其抗微生物特性而闻名,并经常用于各种用途,包括在化妆品和个人护理产品中用作防腐剂;该化合物在水中可中中中可溶,在有机溶剂中更易溶,反映其因芳香环造成的疏水性;安全数据表明,如果浸入或吸入,可能会有害,并应当采取适当的防范措施;此外,该化合物还可能发生各种典型的化学反应,例如,电药替代和氧化,使其在有机合成中成为多用途的中间体.

结构式图片

相似化合物

58020-38-5 1125-66-2 32749-00-1

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上下游产品

4-chloro-3-isopropyl-phenol 4-allyloxy-1-chloro-2-ethyl-benzene 1-chloro-2-ethyl-4-(3-nitrophenoxy)benzene 5-(4-chloro-3-ethyl-phenoxy)-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-quinoline 3-(4-chloro-3-ethylphenoxy)aniline

合成工艺路线路线简述

    4-氯-3-异丙基苯酚 反应生成2,4-Dichloro-3-Isopropyl-6-Nitrophenol,4-氯-3-乙基苯酚
    参考文献:Process For Preparing 2,4-Dichloro-3-Alkyl-6-Nitrophenols
    标题:Process For Preparing 2,4-Dichloro-3-Alkyl-6-Nitrophenols
    摘要:制备用于彩色摄影中氰染料偶联剂的中间体2-4-二氯-3-烷基-6-硝基苯酚的方法是通过磺化4-氯-3-烷基-苯酚以获得5-氯-4-烷基羟基苯磺酸,将这些酸在水相中氯化以获得3,5-二氯-4-烷基-2-羟基苯磺酸,然后对这些磺酸进行硝化.

    海关参考信息

    专利信息


    专利号:US-10040752-B2
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
    发明人:MKRTCHYAN GNEL; YAO QINGWEI
    权利人:CODY LABORATORIES INC
    摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-2019002394-A1
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

    专利号:CA-3170288-A1
    优先权日:2020-03-04
    标题:Synthesis of novel ep4 antagonist and use in cancer and inflammation

    专利号:EP-4116291-A1
    优先权日:2020-03-04
    标题:Synthesis of novel ep4 antagonist and use in cancers and inflammations

    专利号:US-2023125494-A1
    优先权日:2020-03-04
    标题 :Synthesis of novel ep4 antagonist and use in cancer and inflammation
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    主要参考文献

    [参考文献]: A M Low, Et Al. Actions Of 4-Chloro-3-Ethyl Phenol On Internal Ca2+ Stores In Vascular Smooth Muscle And Endothelial Cells. Br J Pharmacol. 1997 Oct;122(3):504-10.
    [参考文献]: Aniko Varadi, Et Al. Dynamic Imaging Of Endoplasmic Reticulum Ca2+ Concentration In Insulin-Secreting Min6 Cells Using Recombinant Targeted Cameleons: Roles Of Sarco(Endo)Plasmic Reticulum Ca2+-Atpase (Serca)-2 And Ryanodine Receptors. Diabetes. 2002 Feb:51 Suppl 1:S190-201.
    [参考文献]: Bo Zeng, Et Al. The Ryanodine Receptor Agonist 4-Chloro-3-Ethylphenol Blocks Orai Store-Operated Channels. Br J Pharmacol. 2014 Mar;171(5):1250-9.
    [参考文献]: C Y Kwan, Et Al. Dynamic Digital Fluorescence Ratio Imaging Of Cell Calcium In Vascular Endothelial Cells. Zhongguo Yao Li Xue Bao. 1999 May;20(5):385-90.
    [参考文献]: F Larini, Et Al. A Ryanodine Receptor-Like Ca2+ Channel Is Expressed In Nonexcitable Cells. Mol Pharmacol. 1995 Jan;47(1):21-8.

    合成参考文献


    参考文献:10.1017/s0265021502000248|10.1097/00003643-200202000-00011
    摘要:Gerbershagen MU, Wappler F, Fiege M, Weihorn R, Alberts PA, von Breunig F, Schulte Esch J. In vitro effects of 4-chloro-3-ethylphenol in skeletal muscle preparations from malignant hyperthermia susceptible and normal swine. European Journal of Anaesthesiology. 2002 Feb;19(2):135–40. doi: 10.1097/00003643-200202000-00011.
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