CAS: 2005-43-8; 2-Bromoquinoline

相似化合物

1334405-59-2 891842-50-5 159870-91-4

上下游产品

CAS号59-31-4 2-羟基喹啉 | CAS号1613-37-2 喹啉-N-氧化物 | CAS号20151-40-0 2,4-二溴喹啉 | CAS号612-62-4 2-氯喹啉 | CAS号74857-04-8 2,2'-diquinolyl... | CAS号91-22-5 喹啉 | CAS号7726-95-6 溴素 | CAS号7789-60-8 三溴化磷 | CAS号347-42-2 2-三氟甲基喹啉 | CAS号5470-96-2 2-喹啉甲醛 | CAS号22190-12-1 2-(苯基硫)喹啉 | CAS号31456-25-4 1H-Pyrano[3',4'... | CAS号91-22-5 喹啉 | CAS号7689-03-4 喜树碱 | CAS号612-96-4 2-苯基喹啉 | CAS号25770-52-9 4-甲基-N-2-喹啉基苯磺酰胺 | CAS号263256-86-6 4-(Quinolin-2-y... | CAS号27104-55-8 2-Quinolinemeth...

1-甲基-2-喹啉酮置于1,3-二溴-1,3,5-三嗪-2,4,6-三酮,三苯基膦体系中,用 Neat (No Solvent) 用作溶剂,化学反应 16.0H,以78%的收率获得2-溴喹啉
参考文献:Development Of A Facile And Inexpensive Route For The Preparation Of α-Halobenzopyridines From α-Unsubstituted Benzopyridines
标题:Development Of A Facile And Inexpensive Route For The Preparation Of α-Halobenzopyridines From α-Unsubstituted Benzopyridines
摘要:A Facile And Inexpensive Route For The Preparation Of Alpha-Halobenzopyridines From Alpha-Unsubstituted Benzopyridines Via N-Methylbenzopyridin-Alpha-Ones Was Developed. Alpha-Unsubstituted Benzopyridines Were Converted Easily Into The Corresponding N-Methylbenzopyridin-Alpha-Ones,Which Were Halogenated Using Pph3-Tcica Or Pph3-Dbica Without Using Solvent To Give A-Halobenzopyridines.
Doi:10.3987/com-15-13234

专利信息

专利号:US-9115128-B2
优先权日:2013-06-06
标 题 :Compounds of 3-(5-substituted Oxy-2, 4-dinitrophenyl)-2-oxo-propionic acid ester, synthesis and applications thereof
发明人：PUTHIAPARAMPIL TOM THOMAS; SAMBASIVAM GANESH; GOVINDA RAJULU GAVARA; KORAMANGALA RAVINDRA CHANDRAPPA
权利人:ANTHEM BIOSCIENCES PVT LTD; ANTHEM BIOSCIENCES PVT LTD
摘要:Synthesis of the novel compound 3 (3-(5-substituted Oxy-2,4-dinitro-phenyl)-2-oxo-propionic acid ester) to make Pyrroloquinoline quinone (PQQ) and using it for pharmaceutical purposes is described. More specifically, this disclosure relates to synthesizing the PQQ in an efficient method by using a novel intermediate Formula 1 resulting in a shorter process and higher yield of PQQ. A unique process to make sodium compound of PQQ using either sodium hydroxide and/or sodium carbonate is also shown.

专利号:US-10266467-B2
优先权日:2017-08-02
标 题:Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols
发明人：CHAKRABORTY SUMIT; HEMBRE ROBERT THOMAS
权利人:EASTMAN CHEM CO
摘要:A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H 2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H 2 . The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.

专利号:US-3708477-A
优先权日:1968-06-27
标 题:Process of total synthesis of cephalosporin derivatives and intermediates
发明人：MARTEL J; HEYMES R
权利人:ROUSSEL UCLAF
摘要:PROCESS FOR THE PREPARATION OF RACEMIC OR OPTICALLYACTIVE CEPHALOSPORINE DERIVATIVES OF THE FORMULA 2,3-(-CO-N(-R1)-CH2-),7-NH2-2-CEPHEM WHEREIN R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL, SUBSTITUTED AKYL, ARYL AND SUBSTITUTED ARYL, WHICH COMPRISES THE STEPS OF REACTING AN AMINO ACID OF THE FORMULA R1-NH-CH2-CH2-COOH WITH BENZYL ALCOHOL, CONDENSING THE BENZYL ESTER THUS OBTAINED WITH AN OXALATE, CONVERTING THE BENZYL ESTER OF 2,3DIOXI-4-CARBOXY-PYRROLIDINE INTO THE CORRESPONDING ACID, SUBJECTING SAID ACID TO AMINOMETHYLATION, THUS YIELDING A COMPOUND OF THE FORMULA 1-R1,3-OH,4-(R'-N(-R'')-CH2-)PYRROL-3-IN-2-ONE CONVERTING SAID COMPOUND INTO THE CORRESPONDING 4-ACYLTHIOMETHYL DERIVATIVE, CONVERTING SAID DERIVATIVE INTO THE CORRESPONDING 4-THIOMETHYL DERIVATIVE, CONDENSING SAID DERIVATIVE WITH AN ENAMINE OF THE FORMULA R-OOC-C(-Y)=CH-NH2 TO OBTAIN A THIAZINE DERIVATIVE OF THE FORMULA 2-(Y-CH(-COO-R)-),5-R1-2,3,4,5,6,7-HEXAHYDRO-PYRROLO (3,4-D)-1,3-THIAZIN-4-ONE CONVERTING SAID THIAZINE DERIVATIVE INTO A COMPOUND OF THE FORMULA 2-(H2N-CH(-COOH)-),5-R1-2,3,4,5,6,7-HEXAHYDRO-PYRROLO (3,4-)-1,3-THIAZIN-4-ONE SUBJECTING SAID COMPOUND TO THE ACTION OF A TRITYLATION AGENT, RECOVERING THE THREO ISOMER OF THE TRITYLATED DERIVATIVE, LACTAMIZING SAID THREO ISOMER TO OBTAIN THE Y-LACTAM OF DL-6H,7H-CIS-7-TRITYLAMINO-3-AMINOALKYL-CEPH 3-EME-4-CARBOXYLIC ACID, DETRITYLATING SAID Y-LACTAM AND RECOVERING SAID RACEMIC OF OPTICALLY ACTIVE CEPHALOSPORIN DERIVATIVES. THESE COMPOUNDS ARE USEFUL AS INTERMEDIATES IN THE PREPARATION OF THE CORRESPONDING 7ACYLAMINO DERIVATIVES OF THE FORMULA 2,3-(-CO-N(-R1)-CH2-),7-(R2-NH-)-2-CEPHEM WHEREIN R1 HAS THE ABOVE DEFINITION AND R2 IS THE ACYL OF AN ORGANIC CARBOXYLIC ACID WHICH COMPOUNDS ARE ALSO PART OF THE INVENTION AND ARE USEFUL AS ANTIBIOTICS.

专利号:US-8921580-B2
优先权日:2012-05-09
标 题 :Methods and systems for the formation of cyclic carbonates
发明人：HATTON TREVOR ALAN; JAMISON TIMOTHY F; KOZAK JENNIFER AIDEN; SIMEON FRITZ; WU JIE
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are inventive methods for synthesis of cyclic carbonates from CO 2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.

专利号:US-7074932-B2
优先权日:1999-06-24
标题 :Preparation of quinoline-substituted carbonate and carbamate derivatives
发明人：ALLEN MICHAEL S; PREMCHANDRAN RAMIYA H; CHANG SOU-JEN; CONDON STEPHEN; DEMATTEI JOHN A; KING STEVEN A; KOLACZKOWSKI LAWRENCE; MANNA SUKUMAR; NICHOLS PAUL J; PATEL HEMANT H; PATEL SUBHASH R; PLATA DANIEL J; STONER ERIC J; TIEN JIEN-HEH J; WITTENBERGER STEVEN J
权利人:ALLEN MICHAEL S; PREMCHANDRAN RAMIYA H; CHANG SOU-JEN; CONDON STEPHEN; DEMATTEI JOHN A; KING STEVEN A; KOLACZKOWSKI LAWRENCE; MANNA SUKUMAR; NICHOLS PAUL J; PATEL HEMANT H; PATEL SUBHASH R; PLATA DANIEL J; STONER ERIC J; TIEN JIEN-HEH J; WITTENBERGER STEVEN J
摘要:The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

专利号:US-2019039978-A1
优先权日:2017-08-02
标 题:Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols