CAS: 2881-63-2; Ethyl 3-(4-Chlorophenyl)-3-Oxo-Propionate

上下游产品

Ethyl 2-(4-Chlorobenzoyl)Acetoacetate 13892-47-2
Ethyl 3-Hydroxy-3-(4-Chlorophenyl)Propanoate 70200-14-5
对氯苯乙酮 Para-Chloroacetophenone 99-91-2

Ethyl 3-Hydroxy-3-(4-Chlorophenyl)Propanoate置于重铬酸体系中,用 乙醚 用作溶剂,化学反应 4.0H,以75%的收率获得(4-氯苯甲酰基)乙酸乙酯
参考文献:通过ru(II)-Binap催化的不对称加氢合成(R)-(-)-Baclofen的对映选择性
标题:通过ru(II)-Binap催化的不对称加氢合成(R)-(-)-Baclofen的对映选择性
摘要:已经描述了一种短而有效的对映选择性合成(R)-(-)-Baclofen(一种选择性的gaba B激动剂)的方法,其总收率为ee的26%和90%.Ru(II)-(S)-Binap催化cc和co基团的不对称氢化反应是将立体异构中心引入分子的关键步骤.
Doi:10.1016/s0957-4166(03)00024-7

专利信息

专利号:US-8962839-B2
优先权日:2010-11-19
标题:Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof
发明人：ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN
权利人:ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN; ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO LTD
摘要:The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.

专利号:CN-107876092-A
优先权日:2017-11-24
标 题 :High Stability Titanium Catalyst for the Synthesis of Benzyl Carbonate and Diphenyl Carbonate by Transesterification