CAS: 352-33-0; 1-Chloro-4-Fluorobenzene

上下游产品

fluorobenzene 4-fluoroaniline 4-Fluorophenol para-dichlorobenzene 4-chloro-2,6-dinitrophenol 1-chloro-4-fluoro-2-nitrobenzene 2-fluoro-5-chloronitrobenzene r,3t,4ξ,5t,6c-heptachloro-4ξ-fluoro-cyclohexane1,1,2r,3t,4ξ,5t,6c-heptachloro-4ξ-fluoro-cyclohexane

对氯苯胺置于氢氟酸,Sodium Nitrite体系中,用91%的收率获得1-氯-4-氟苯
参考文献:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
标题:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
摘要:通过将氟化氢与碱溶液结合使用,成功地实现了包括杂芳族化合物在内的氨基芳烃的一锅式脱氨氟化,即氨基芳烃的重氮化,然后将相应的重氮离子进行原位氟脱氮,以高产率生产了氟芳烃.已发现重氮化阶段在有效生产氟代芳烃中起着最重要的作用.它受到hf溶液组成的极大影响,并通过在谨慎控制的条件下使用适量的碱(例如吡啶)来增强.光化学方法有效地促进了氟脱重氮化阶段,从而以高收率提供了具有极性取代基(如羟基,硝基等)的氟代芳烃.
Doi:10.1016/0040-4020(95)00867-8

专利信息

专利号:US-2010016607-A1
优先权日:2006-12-11
标题:Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics
发明人：DOLBIER JR WILLIAM R; JANMANCHI KRISHNA MURTHY
权利人:UNIV FLORIDA
摘要:The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O 2 and HF.

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-5831128-A
优先权日:1996-12-04
标题 :Synthesis of aromatic amines from chloroamatics
发明人：BELLER MATTHIAS; RIERMEIER THOMAS; REISINGER CLAUS PETER; HERRMANN WOLFGANG ANTON; GEISSLER HOLGER
权利人:HOECHST AG
摘要:The present invention relates to a process for the preparation of aromatic amines of the formula (I) n n Ar--NR.sup.1 R.sup.2 (I) n n in which Ar is ##STR1## and R 3 to R 9 independently of one another are hydrogen, C 1 -C 8 -alkyl, alkoxy-(C 1 -C 8 ), acyloxy-(C 1 -C 8 ), OAr, Ar, fluorine, chlorine, bromine, iodine, OH, NO 2 , CN, CO 2 H, CHO, SO 3 H, SO 2 R, SOR, NH 2 , NH-alkyl-(C 1 -C 12 ), N-alkyl 2 -(C 1 -C 12 ), NHCO-alkyl-(C 1 -C 12 ), CO-alkyl-(C 1 -C 12 ), NHCHO, COAr, CO 2 Ar, CF 3 , CONH 2 , CHCHCO 2 R, POAr 2 , PO-alkyl 2 -(C 1 -C 12 ), 5-ring heteroaryl, 6-ring heteroaryl, Si-alkyl 3 -(C 1 -C 12 ), where R=alkyl(C 1 -C 8 ), aryl(C 5 -C 10 ) and R 1 and R 2 independently of one another are hydrogen, C 1 -C 12 -alkyl, Ar as defined above, 5-ring heteroaryl, 6-ring heteroaryl, by reacting chloroaromatics of the formula II n n Ar--Cl (II) n n with ammonia or primary or secondary amines of the formula III n n R.sup.1 R.sup.2 NH (III) n n in which Ar and R 1 and R 2 are as defined above, which comprises reacting the starting materials in the presence of a palladium catalyst, a strong base and a halide cocatalyst in an inert solvent at temperatures of 80°-200° C.

专利号:US-4453012-A
优先权日:1982-04-22
标 题 :Process for the preparation of phenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

专利号:US-4454350-A
优先权日:1982-01-21
标题:Process for the acylation of halo- or trihalomethylbenzenes
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the acylation of halo- or trihalomethylbenzenes, wherein a halo- or trihalomethylbenzene is reacted with a carboxylic acid, a precursor or a derivative thereof in the presence of boron trifluoride in an amount such that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having a phytosanitary (e.g., herbicidal) or pharmaceutical activity.