CAS: 5194-32-1; 2-Methylpyrimidine-5-Carboxylic Acid

相似化合物

90905-33-2 2239-83-0 5571-03-9

上下游产品

CAS号2134-38-5 2-甲基嘧啶-5-甲酸乙酯 | CAS号7752-78-5 2-甲基-5-溴嘧啶 | CAS号124-38-9 二氧化碳

Sodium 2-Methylpyrimidine-5-Carboxylate置于盐酸体系中,用 水 作为反应溶剂,化学反应生成 2-甲基-5-嘧啶甲酸
参考文献:Wo2006/97691
标题:Wo2006/97691

专利信息

专利号:US-10494372-B2
优先权日:2014-11-07
标 题 :Synthesis of copanlisib and its dihydrochloride salt
发明人：PETERS JAN-GEORG; RUBENBAUER PHILIPP; GÖTZ DANIEL; GROSSBACH DANJA; MAIS FRANZ-JOSEF; SCHIRMER HEIKO; STIEHL JUERGEN; LOVIS KAI; LENDER ANDREAS; SEYFRIED MARTIN; ZWEIFEL THEODOR; MARTY MAURUS; WEINGÄRTNER GÃœNTER
权利人:Bayer Pharma AG
摘要:The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.

专利号:US-10035803-B2
优先权日:2014-11-07
标 题:Synthesis of copanlisib and its dihydrochloride salt
发明人：PETERS JAN-GEORG; STIEHL JÃœRGEN; LOVIS KAI
权利人:Bayer Pharma AG
摘要:The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.

专利号:US-4835280-A
优先权日:1985-01-18
标 题 :Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles
发明人：MARTENS ALFRED; HOELCK JENS-PETER; BERGER HERBERT; MUELLER-BECKMAN BERND; STREIN KLAUS; ROESCH EGON
权利人:BOEHRINGER MANNHEIM GMBH
摘要:The present invention provides Indolines of the formula: (II) (III) ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: (I) These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2018282337-A1
优先权日:2014-11-07
标题 :Synthesis of copanlisib and its dihydrochloride salt

专利号:US-2017327505-A1
优先权日:2014-11-07
标题 :Synthesis of copanlisib and its dihydrochloride salt