CAS: 626-51-7; 3-Methylglutaric Acid

该化合物是一种该化合物是一种在水和极有机溶剂中可溶解的白色晶状固体,该化合物因其在有机合成中,特别是在生产药品,农用化学品和特殊聚合物方面作为多用途中间体的作用而受到重视,其结构特征,包括一个分支甲基组,有助于改变目标分子的物理化学特性. 3-甲基乙基甘酸还用于生物化学研究,作为代谢研究的前体或类同体,其稳定性和明确界定的再活性简介确保合成应用的一贯性能.

结构式图片

相似化合物

4457-71-0 75143-89-4 4839-46-7

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上下游产品

dihydro-4-methyl-2(3H)-furanone potassium cyanide 5-methylcyclohexan-1,3-dione pulegone 3-methylglutaric anhydride 3-methyl-1,5-pentanedioic acid monomethyl ester dimethyl 3-methylglutarate 3-methyl-glutaric acid dibutyl ester

合成工艺路线路线简述

    四氢-4-甲基-2H-吡喃置于硝酸体系中,用70%的收率获得产物3-甲基戊二酸
    参考文献:Synthesis Of 3-Methylglutaric Acid
    标题:Synthesis Of 3-Methylglutaric Acid
    摘要:
    DOI:10.1007/bf00475468

    海关参考信息

    专利信息


    专利号:US-6177572-B1
    优先权日:1997-08-20
    标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
    发明人:WANG FENGJIANG
    权利人:SEPRACOR INC
    摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.

    专利号:US-2024400608-A1
    优先权日:2021-09-03
    标题:Synthesis of bicycle toxin conjugates, and intermediates thereof
    发明人:WITTY DAVID; LIMB DARREN; MIN BYOUNG JOON; HE LIWEN; SANDERS WILLIAM J; NNANABU ERNEST OBINNA
    权利人:BRICYCLETX LTD
    摘要:The present invention relates to Bicycle toxin conjugates, methods for preparation, and methods of use for treating cancer.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-4341706-A
    优先权日:1980-10-10
    标题 :Process for the preparation of carbapenem antibiotics
    发明人:CHRISTENSEN BURTON G; SHIH DAVID H
    权利人:MERCK & CO INC
    摘要:Disclosed is a process for the synthesis of carbapenem antibiotics I and their pharmaceutically acceptable salts and esters from 1: wherein: R7, R6, R1, R2 and R8 are selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, spirocycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, aralkyl, aralkenyl, aralkynyl, heteroalkyl, heteroaralkyl, heterocyclyl and heterocyclyalkyl.

    专利号:US-11577963-B2
    优先权日:2020-01-17
    标 题 :Method of preparing sparsely pillared organic-inorganic hybrid compound
    发明人:IHM JISOON; PARK SEOK HWAN
    权利人:INNONEP INC
    摘要:Provided is a method of preparing a sparsely pillared organic-inorganic hybrid compound. The method of preparing an organic-inorganic hybrid compound includes: preparing a compound having a gibbsite structure by a method other than a hydrothermal synthesis method, using a trivalent metal cation source, an alkali imparting agent, and a first solvent (S10); and preparing an organic-inorganic hybrid compound by a method other than a hydrothermal synthesis method, using the compound of the gibbsite structure, a divalent metal cation source, dicarboxylic acid, and a second solvent (S20).

    专利号:WO-2025124564-A1
    优先权日:2023-12-15
    标题:Polyester synthesis based on aspartic acid modification
    发明人:ZHANG KECHUN; CHEN XI; LEI TENGFEI; LIU SHENGYANG
    权利人:MINT BIOTECHNOLOGIES CO LTD
    摘要:Provided in the present invention is polyester synthesis based on aspartic acid modification. A monomer of a unique structure of an imide ring is obtained based on aspartic acid and a dibasic acid likely to be cyclized, the monomer is based on the aspartic acid, can be derived from biomass, is low in cost and renewable, meets the requirement of sustainable development, and the unique structure of the monomer can regulate and control various properties of polyester materials, such as the mechanics, temperature resistance, hydrophilicity and hydrophobicity, and crystallization.
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    主要参考文献

    [参考文献]: Barich Dh, Et Al. 3-Methylglutaric Acid As A 13C Solid-State Nmr Standard. Solid State Nucl Magn Reson. 2006 Oct;30(3-4):125-9.
    [参考文献]: Dylan E Jones, Et Al. 3-Methylglutaric Acid In Energy Metabolism. Clin Chim Acta. 2020 Mar;502:233-239.
    [参考文献]: Arun Sreekumar, Et Al. Metabolomic Profiles Delineate Potential Role For Sarcosine In Prostate Cancer Progression. Nature. 2009 Feb 12;457(7231):910-4.
    [参考文献]: F Guneral, Et Al. Age-Related Reference Values For Urinary Organic Acids In A Healthy Turkish Pediatric Population. Clin Chem. 1994 Jun;40(6):862-6.
    [参考文献]: F Scaglia, Et Al. Mitochondrial Dna Depletion Associated With Partial Complex Ii And Iv Deficiencies And 3-Methylglutaconic Aciduria. J Child Neurol. 2001 Feb;16(2):136-8.

    合成参考文献


    参考文献:10.1007/s11095-011-0519-1
    摘要:Mozziconacci O, Haywood J, Gorman EM, Munson E, Schöneich C. Photolysis of Recombinant Human Insulin in the Solid State: Formation of a Dithiohemiacetal Product at the C-Terminal Disulfide Bond. Pharmaceutical Research. 2011 Jul 12;29(1):121–33. doi: 10.1007/s11095-011-0519-1.
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