专利号:US-8178474-B1 优先权日:1999-04-21 标题 :Functionalised solid support for alpha-oxoaldehyde synthesis 发明人:MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE 权利人:MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE; PASTEUR INSTITUT; CENTRE NAT RECH SCIENT 摘要:The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one α-oxoaldehyde function and to the α-oxoaldehyde peptides obtained using this process.
专利号:US-5136034-A 优先权日:1987-02-05 标 题 :Synthesis of chiral thioacetals and thioethers 发明人:YOUNG ROBERT N; THERIEN MICHEL; GAUTHIER JACQUES-YVES; ZAMBONI ROBERT; BELLEY MICHEL L 权利人:MERCK FROSST CANADA INC 摘要:Thioacids, thiols, an acid, and an aldehyde are used to produce chiral thioacetals of the general formula. I The compounds are leukotriene antagonists.
专利号:EP-1888746-B1 优先权日:2005-06-07 标题:Ordered multi-step synthesis by nucleic acid-mediated chemistry 发明人:LIU DAVID R; SNYDER THOMAS M 权利人:HARVARD COLLEGE 摘要:The present invention provides methods and compositions for performing ordered multi-step syntheses by nucleic acid-mediated chemistry. This approach provides increased yields, and control over the preparation, of products produced via sequential, multi-step syntheses in a single reaction vessel.
参考标题:Multistep Dna-Templated Reactions For The Synthesis Of Functional Sequence Controlled Oligomers 作者:Mireya L. Mckee,Phillip J. Milnes,Jonathan Bath,Eugen Stulz,Andrew J. Turberfield,Rachel K. O'Reilly |发布日期:2010.10.18 摘要:Biomimetic: A Strand Displacement Mechanism Was Designed To Permit Dna‐templated Synthesis Of Functional Oligomers Of Arbitrary Length (See Scheme). Key Features Of The Mechanism Are That Successive Coupling Reactions Take Place In Near‐identical Environments And That Purification Is Only Necessary In The Last Synthesis Step.
合成参考文献
摘要:Austin, W. F.; Kowalczyk, J. J.; Dudley, G. B.; Danheiser, R. L., Science of Synthesis, (2006) 23, 254.