CAS: 695-53-4; 5,5-Dimethyloxazolidine-2,4-Dione

相似化合物

2346-26-1 27770-23-6 52387-52-7

上下游产品

CAS号80-55-7 2-羟基异丁酸乙酯 | CAS号3019-71-4 三氯乙酰基异氰酸酯 | CAS号57-13-6 尿素 | CAS号26212-60-2 (2-ethoxy-5,5-d... | CAS号77609-28-0 (α-bromo-isobut... | CAS号77609-26-8 ethyl (E)-(2-br... | CAS号2110-78-3 2-羟基异丁酸甲酯 | CAS号127-48-0 3,5,5,-三甲基恶唑烷-2,4-二酮 | CAS号6453-39-0 5,5-Dimethyl-2-... | CAS号594-61-6 2-羟基异丁酸 | CAS号7664-41-7 氨 | CAS号127-48-0 3,5,5,-三甲基恶唑烷-2,4-二酮 | CAS号86970-75-4 5,5-dimethyl-3-... | CAS号520-77-4 依沙双酮

三甲双酮置于human Liver Microsomes体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 0.33H,反应生成 5,5-二甲基噁唑烷-2,4-二酮
参考文献:Trimethadione Metabolism By Human Liver Cytochrome P450: Evidence For The Involvement Of Cyp2E1
标题:Trimethadione Metabolism By Human Liver Cytochrome P450: Evidence For The Involvement Of Cyp2E1
摘要:1. Caucasian Liver Samples Were Used In This Study. N-Demethylation Of Trimethadione (Tmo) To Dimethadione (Dmo) Was Monitored In The Presence Of Chemical Inhibitors Of Cyps,Such As Fluconazole,Quinidine,Dimethyl-Nitrosamine,Acetaminophen,Phenacetin,Chlorzoxazone And Mephenytoin. Trimethadione N-Demethylation Was Selectively Inhibited By Dimethylnitrosamine And Chlorzoxazone (> 50%) And Weakly Inhibited By Tolbutamide (12 %) And Fluconazole (22 %),Whereas Other Inhibitors Showed No Effect. This Result Suggested That Tmo Metabolism To Dmo Is Mainly Mediated By Cyp2E1 And Marginally By Cyp2C And Cyp3A4.2. Fifteen Human Livers Were Screened And Interindividual Variability Of Tmo N-Demethylation Activity Was 3-Fold. Chlorzoxazone 6-Hydroxylation Activity Was Also Measured And Both Activities Were Significantly Correlated (R = 0.735,P < 0.01).3. Dmo Production By Human Cdna Expressed Cyp Enzymes Was Observed Mainly For Cyp2E1 (10.8 Nmol/tube),Marginally For Cyp2C8 (0.22 Nmol/tube) And Not Detectable For Other Cyp Enzymes.4. These Results Indicate That Tmo Metabolism Is Primarily Catalysed By Cyp2E1 And That Trimethadione Would Be A Suitable Selective Probe Drug For The Estimation Of Human Cyp2E1 Activity In Vivo.
DOI:10.1080/004982598238930

专利信息

专利号:EP-1473330-B1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-6441189-B1
优先权日:2000-03-31
标 题 :Process for the preparation of matrix metalloproteinase inhibitors
发明人：BAILEY ANNE E; HILL DAVID R; HSIAO CHI-NUNG W; KURUKULASURIYA RAVI; WITTENBERGER STEVE; MCDERMOTT TODD; MCLAUGHLIN MAUREEN A
权利人:ABBOTT LAB
摘要:The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:WO-2005075459-A1
优先权日:2004-02-03
标题:Synthesis of cyanoimino-benzoimidazoles

专利号:JP-2007520493-A
优先权日:2004-02-03
标 题 :Synthesis of cyanoiminobenzimidazole