CAS: 86357-13-3; 1,3-Diacetoxy-2-(Acetoxymethoxy)Propane

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CAS号103824-51-7 2-(methoxymetho... | CAS号70905-45-2 1-氯-2-(氯甲基)-3,5... | CAS号108-24-7 乙酸酐 | CAS号53883-86-6 2-(chloromethox... | CAS号127-08-2 醋酸钾 | CAS号127-09-3 乙酸钠 | CAS号86357-14-4 三乙酰更昔洛韦 | CAS号86357-16-6 acetic acid,2-(...

1-氯-2-(氯甲基)-3,5-二氧杂己烷置于三氟化硼乙醚体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 1,3-二乙酰氧-2-(乙酰氧基甲氧基)丙烷
参考文献:与9-[(1,3-二羟基-2-丙氧基)甲基]鸟嘌呤有关的无环嘧啶对疱疹病毒的影响.
标题:与9-[(1,3-二羟基-2-丙氧基)甲基]鸟嘌呤有关的无环嘧啶对疱疹病毒的影响.
摘要:已合成了一系列与有效的抗疱疹药9-[((1,3-二羟基-2-丙氧基)甲基]鸟嘌呤(1,Bw B759U)相关的嘧啶,它们均含有相同的无环链.其中一些化合物是天然存在的碱,胞嘧啶,尿嘧啶和胸腺嘧啶的衍生物.其他包括其中胞嘧啶和尿嘧啶部分的5-位被溴,碘,氟,甲基和氨基取代的化合物.胞嘧啶衍生物的其他变体是5-氮杂,2-巯基,4-甲基氨基,4-二甲基氨基和异胞嘧啶同源物.还制备了4-氨基嘧啶加合物.抗病毒测试表明,1-[((1,3-二羟基-2-丙氧基)甲基]胞嘧啶(18,Bw A1117U)在抵抗人巨细胞病毒和爱泼斯坦巴尔病毒的效力方面与鸟嘌呤类似物相当.
DOI:10.1021/jm00396A021

专利信息

专利号:US-7078524-B2
优先权日:2002-11-22
标题:Process for the synthesis of ganciclovir
发明人：BABU JAYACHANDRA SURESH; RAY PURNA CHANDRA; KUMAR YATENDRA; KHANDURI CHANDRA HAS
权利人:RANBAXY LAB LTD
摘要:The present invention relates to an industrial useful process for the synthesis of antiviral compound, ganciclovir which comprises dissolving a mixture containing N-7 and N-9 isomers of structural formulae, II and III, respectively: n n nin a solvent or a mixture of solvents; separating the N-7 and N-9 isomers; and hydrolizing the N-9 isomer to obtain ganciclovir.

专利号:EP-1565469-A1
优先权日:2002-11-22
标题:Process for the synthesis of ganciclovir
发明人：BABU JAYACHANDRA SURESH; RAY PURNA CHANDRA; KUMAR YATENDRA; KHANDURI CHANDRA HAS
权利人:RANBAXY LAB LTD
摘要:The present invention relates to an industrial useful process for the synthesis of antiviral compound, ganciclovir.

专利号:US-5648489-A
优先权日:1994-05-17
标题 :Syntheses of acyclic guanine nucleosides
发明人：CHU CHUNG K; DU JINFA; WANG CHUNGUANG
权利人:UNIV GEORGIA
摘要:A method is provided for the synthesis of synthesis of acyclic purine nucleosides, particularly 9-(2-hydroxy-ethoxymethyl)-guanine (acyclovir) and 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine ('DHPG') where the N2,N9-diprotected guanine is reacted with CH3C(O)OCH2O(CH2)2)OC(O)CH3 or 2-acetoxymethoxy-1,3-diacetoxypropane, respectively, in the presence of a mixture of an acid and acetic anhydride, or in the presence of an acid, where the acid can be phosphoric acid or polyphosphoric acid.

专利号:US-6043364-A
优先权日:1996-02-22
标 题:Regiospecific process for synthesis of acyclic nucleosides
发明人：KUMAR ASHOKE; SINGH DHARMENDRA; WANI MUKESH JAGANNATH; JOSHI NARENDRA SRIRAM; THOMBRE PRAVIN SAHADEV; RAWAT AJAY SINGH
权利人:LUPIN LAB LTD
摘要:N-7 isomer of the formula is converted into a N-9 isomer of the formula by heating a suspension of the N-7 isomer in an alkylating agent of the formula

专利号:US-5792868-A
优先权日:1991-09-18
标题 :Process for producing acyclic nucleosides and process for separating purine nucleosides
发明人：IZAWA KUNISUKE; KOGUCHI YOSHIHITO; SHIRAGAMI HIROSHI
权利人:AJINOMOTO KK
摘要:Herein is disclosed a novel and industrially advantageous process for synthesizing acyclic nucleosides such as acyclovir and ganciclovir from ribonucleosides, which process comprises adding an acid catalyst and an acid anhydride to a solution of a ribonucleoside such as guanosine and an ester derivative of an acyclic sugar, and heating the mixture, whereby a transglycosilation reaction takes place between the ribose moiety of the ribonucleoside and the ester derivative of the acyclic sugar. Herein is also disclosed an industrially favorable method for the separation of 9-substituted purine nucleosides which are important intermediates for the synthesis of acyclic nucleosides such as acyclovir, ganciclovir, and the like from ribonucleosides, which method comprises crystallizing only the 9-isomer from a solution or suspension containing both a 9-substituted purine nucleoside and a 7-substituted purine nucleoside by cooling the solution or/and by adding a crystallizing solvent thereto.

专利号:US-2004102628-A1
优先权日:2002-11-22
标 题:Process for the synthesis of ganciclovir