1,2,4-三乙苯置于三氯化铝体系中,化学反应生成1,3,5-三乙基苯 参考文献:The Action Of Aluminum Chloride On Aromatic Hydrocarbons. Iii. The Polyethylbenzenes And Tetramethylbenzenes 标题:The Action Of Aluminum Chloride On Aromatic Hydrocarbons. Iii. The Polyethylbenzenes And Tetramethylbenzenes 摘要: Doi:10.1021/ja01857A074
专利信息
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-6355826-B1 优先权日:1997-09-17 标题:Synthesis of stable nitrile oxide compounds 发明人:PARKER DANE KENTON 权利人:GOODYEAR TIRE & RUBBER 摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.
专利号:US-7094943-B2 优先权日:1998-04-27 标 题 :Solution phase biopolymer synthesis 发明人:KOESTER HUBERT; WOERL RALF 权利人:KOESTER HUBERT; WOERL RALF 摘要:Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X 1 ) n , where Sp is a highly symmetrical moiety such that all X 1 groups are equivalent. X 1 is a functional group that is suitable for biopolymer synthesis, including OH, SH, NH 2 , COOH and the like. Biopolymers that may be produced using the methods provided include oligonucleotides, peptides, protein nucleic acids (PNAs) and oligosaccharides. Analogs of the biopolymers may also be prepared using the methods.
专利号:EP-1905753-A1 优先权日:2006-09-26 标题:Synthesis method of diamondoid 发明人:WATANABE KATSUYUKI; WATANABE YASUFUMI 权利人:FUJIFILM CORP 摘要:A synthesis method of a diamondoid is characterized in that the diamondoid is synthesized from a diamondoid precursor in the presence of at least one Lewis acid and at least one compound capable of reacting with the Lewis acid to generate an acid.
专利号:US-7741487-B2 优先权日:2004-08-26 标题 :Method for producing quaterrylene-3,4:13, 14-tetracarboxy diimides by direct synthesis 发明人:KOENEMANN MARTIN; BOEHM ARNO; BIDLINGMAIER HERMANN; RIEGER REINHOLD; BLASCHKA PETER; REICHELT HELMUT; KRIEGER MATTHIAS 权利人:BASF AG 摘要:A process for preparing quaterrylene-3,4:13,14-tetracarboximides of the general formula I n nin whichn nR, R′ are each independently hydrogen or optionally substituted C 1 -C 30 -alkyl, C 5 -C 8 -cycloalkyl or aryl or hetaryl;n nwhich comprises reacting a perylene-3,4-dicarboximide of the general formula IIan n nin the presence of a base-stable, high-boiling, organic solvent and of an alkali metal base or alkaline earth metal base, with a perylene-3,4-dicarboximide of the general formula IIbn n nin which X is hydrogen, bromine or chlorine.
专利号:EP-1953140-A1 优先权日:2007-01-24 标 题 :Process for the preparation of ezetimibe and derivatives thereof 发明人:STIMAC ANTON; MOHAR BARBARA; STEPHAN MICHEL; BEVC MOJCA; ZUPET ROK; GARTNER ANDREJ; KROSELJ VESNA; SMRKOLJ MATEJ 权利人:KRKA 摘要:The present invention relates to the method of preparing of ezetimibe and in particular to novel intermediates for its synthesis and an improved process for preparing such intermediates. Said intermediates may be obtained in high yields and purity in a fast and cost efficient manner. The present invention relates to a novel crystalline form of ezetimibe as well.
参考标题:A Metal‐free Direct Arene C−h Amination 作者:Tao Wang,Marvin Hoffmann,Andreas Dreuw,Edina Hasagić,Chao Hu,Philipp M. Stein,Sina Witzel,Hongwei Shi,Yangyang Yang,Matthias Rudolph,Fabian Stuck,Frank Rominger,Marion Kerscher,Peter Comba,A. Stephen K. Hashmi |发布日期:2021.6.8 摘要:The Synthesis Of Aryl Amines Via The Formation Of A C−n Bond Is An Essential Tool For The Preparation Of Functional Materials, Active Pharmaceutical Ingredients And Bioactive Products. Usually, This Chemical Connection Is Only Possible By Transition Metal-Catalyzed Reactions, Photochemistry Or Electrochemistry. Here, We Report A Metal-Free Arene C−h Amination Using Hydroxylamine Derivatives Under Benign
合成参考文献
参考文献:10.1021/jm200560r 摘要:Lozano V, Aguado L, Hoorelbeke B, Renders M, Camarasa MJ, Schols D, Balzarini J, San-Félix A, Pérez-Pérez MJ. Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids. J Med Chem. 2011 Aug 11;54(15):5335–48. doi: 10.1021/jm200560r. 参考文献:10.1107/s1600536811009639 摘要:Takahashi H. 4-Chloro-2',4',6'-triethyl-benzophenone: a redetermination. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o935.