合成目标产物 Hexadecyldimethylamine 主要起始原料 Dimethylamine And 1-Bromohexadecane
(文献来源)合成步骤主要原料 Dimethylamine 和 1-Bromohexadecane
1-十六烷醇置于盐酸,Zinc(II) Chloride体系中,用 水 用作溶剂,化学反应生成十六烷基二甲基叔胺 参考文献:Antimicrobial And Surface-Active Properties Of Cationic Surfactants Based On Chloroalkanes And Alkylbenzenes 标题:Antimicrobial And Surface-Active Properties Of Cationic Surfactants Based On Chloroalkanes And Alkylbenzenes 摘要: Doi:10.1007/bf00779905
专利号:US-6540970-B1 优先权日:1999-11-18 标题:Method for the synthesis of molecular sieves 发明人:STROHMAIER KARL G; VAUGHAN DAVID E W 权利人:EXXON MOBIL CHEM PATENTS INC 摘要:The present invention provides a method for the synthesis of MeAPO molecular sieves which includes the following steps: providing a source of alumina, a source of phosphorus, water, and a template suitable for forming a MeAPO molecular sieve; providing a source of metal (Me) including metal particles, the metal particles measuring, in their largest dimension, equal to or less than five nanometers; providing a water soluble organic solvent capable of solubilizing the source of metal; forming a synthesis mixture from the source of alumina, the source of phosphorus, the water, the template, the source of metal, and the solvent; and forming a MeAPO molecular sieve from the synthesis mixture.
专利号:US-2025215464-A1 优先权日:2022-07-08 标题 :Engineered enzyme for preparing a hydroxylated indanone intermediate useful in the synthesis of belzutifan 发明人:CHEUNG-LEE WAI LING; DIROCCO DANIEL A; GIL AGNIESZKA; HIRAGA KAORI; KIM JUNGCHUL; KOLEV JOSHUA; KOSJEK BIRGIT; MALONEY KEVIN M; SALEHI MARZIJARANI NASTARAN; MCINTOSH JOHN; MCMULLEN JONATHAN P; MOORE JEFFREY C; MURPHY GRANT S; PAN WEILAN; VELASQUEZ VELEZ JUAN E; VERMA DEEPTAK; WINSTON MATTHEW S; XIAO LI; ZHANG VICTORIA 权利人:MERCK SHARP & DOHME LLC 摘要:The present disclosure provides enzymes derived from the fungi Fusarium oxysporum c8D (“FoPip4H enzymesâ€?) having improved properties as compared to a naturally occurring wild-type enzyme including the capability of hydroxylating certain substituted indanones to provide optically pure 3-hydroxyindanones. Also provided are polynucleotides encoding the FoPip4H enzymes, host cells capable of expressing the FoPip4H enzymes, and processes for using the FoPip4H enzymes to synthesize (R)-4-fluoro-3-hydroxy-7-(methylsulfonyl)-2, 3-dihydro-1H-inden-1-one, a useful intermediate in the synthesis of belzutifan.
专利号:US-4291155-A 优先权日:1978-03-14 标 题:Method of making lactone-epoxide copolymer polyols 发明人:BROCHET JACQUES 权利人:UGINE KUHLMANN 摘要:The invention concerns a method for the manufacture of polyols, principally utilizable in the synthesis of polyurethanes, which are ester/ether copolymers with hydroxylated terminal groups obtained by the direct copolymerization of a lactone and a vicinal epoxide in the presence of a chain initiator possessing at least two labile hydrogen atoms per mole and of an alkaline catalyst.
专利号:US-5110929-A 优先权日:1986-08-07 标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles 发明人:PARADIES HENRICH H 权利人:MEDICE CHAM PHARM FABRIK PUTTE 摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.
专利号:US-7547347-B2 优先权日:2005-05-13 标 题 :Synthesis of nano-materials in ionic liquids 发明人:YANG HONG; WANG YONG 权利人:UNIV ROCHESTER 摘要:A method of synthesizing nanoparticles includes: combining at least one stabilizing agent, at least one precursor and an ionic liquid to form a reaction mixture; heating the reaction mixture to a predetermined temperature to form the nanoparticles and cause the nanoparticles to self-separate from the reaction mixture; and collecting the nanoparticles from the reaction mixture. Ionic liquid from which the nanoparticles are separated may be reused.
专利号:US-5973166-A 优先权日:1998-03-02 标 题 :Method for the preparation of maleimides 发明人:MIZORI FARHAD G; DERSHEM STEPHEN M 权利人:DEXTER CORP 摘要:In accordance with the present invention, there are provided improved methods for the preparation of maleimide monomers. This new method for the synthesis of maleimides is clearly superior to those documented in the prior art. Furthermore, the invention method utilizes materials with reduced toxicity, thus the overall process has a minimal impact on the environment. Thus, in accordance with the present invention, it has been discovered that certain amine salts can be successfully used to replace the polar, aprotic solvents cited in the prior art for the cyclodehydration of maleamic acids. The use of these salts provides competitive reaction times and product yields relative to results obtained with the polar, aprotic solvents. These salts have the advantage of having no vapor pressure and, therefore, have no possibility to co-distill with the water produced by the cyclodehydration reaction. Furthermore, such salts can be tailored to have desirable solubility characteristics (i.e., soluble in the refluxing azeotropic solvent, but insoluble at room temperature) that permit their easy removal from the reaction product. Such salts are not destroyed during the cyclodehydration reaction and, therefore, can be efficiently recycled again and again.
[参考文献]: Antonio B Fuertes, Et Al. Synthesis Of Colloidal Silica Nanoparticles Of A Tunable Mesopore Size And Their Application To The Adsorption Of Biomolecules. J Colloid Interface Sci. 2010 Sep 1;349(1):173-80. [参考文献]: Jinlou Gu, Et Al. Sub-150 Nm Mesoporous Silica Nanoparticles With Tunable Pore Sizes And Well-Ordered Mesostructure For Protein Encapsulation. J Colloid Interface Sci. 2013 Oct 1:407:236-42. [参考文献]: Kabir-Ud-Din, Et Al. A 1H Nmr Study Of 1,4-Bis( N-Hexadecyl- N, N-Dimethylammonium)Butane Dibromide/sodium Anthranilate System: Spherical To Rod-Shaped Transition. Colloid Polym Sci. 2006;284(11):1339-1344.
合成参考文献
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