CAS: 114214-49-2; Tert-Butyl 6-Oxa-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate

相似化合物

31865-25-5 897445-50-0 75390-09-9

上下游产品

N-(tert-butoxycarbonyl)-3-pyrroline (+/-)-trans-tert-butyl 3-bromo-4-hydroxypyrrolidine-1-carboxylate tert-butyl diallylcarbamate tert-butyl carbazate tert-butyl (3R,4R)-3-hydroxy-4-methoxypyrrolidine-1-carboxylate (+/-)-tert-butyl trans-3-amino-4-hydroxypyrrolidine-1-carboxylate trans-tert-butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate

N,N-二烯丙基氨基甲酸叔丁酯置于grubbs Catalyst First Generation 间氯过氧苯甲酸体系中,用 二氯甲烷 用作溶剂,化学反应 21.0H,反应生成3-Boc-6-氧杂-3-氮杂二环[3.1.0]己烷
参考文献: 3-Hydroxypyrrolidine Inhibitors Of 5'-Methylthioadenosine Phosphorylase And Nucleosidase[fr] Inhibiteurs 3-Hydroxypyrrolidine De 5'-Méthylthioadénosine Phosphorylase Et Nucléosidase
标题: 3-Hydroxypyrrolidine Inhibitors Of 5'-Methylthioadenosine Phosphorylase And Nucleosidase[fr] Inhibiteurs 3-Hydroxypyrrolidine De 5'-Méthylthioadénosine Phosphorylase Et Nucléosidase
摘要:本发明涉及一般式(i)的3-羟基吡咯烷化合物,这些化合物是5'-甲硫腺苷磷酸化酶或5'-甲硫腺苷核苷酸酶的抑制剂.该发明还涉及在治疗希望抑制5'-甲硫腺苷磷酸化酶或5'-甲硫腺苷核苷酶的疾病或症状中使用这些化合物,包括癌症,并且涉及含有这些化合物的药物组合物.

专利信息

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-9937151-B2
优先权日:2010-06-18
标题 :Carbapenem antibacterials with gram-negative activity
发明人：CHOI WOO-BAEG; GRUSZECKA-KOWALIK EWA; JOO HYUNG-YEUL; LIU SHUANGPEI; MAO SHULI; LI YONGFENG; KIM DEOG-IL
权利人:FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

专利号:US-9212161-B2
优先权日:2010-07-01
标 题:Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors

专利号:US-8518952-B2
优先权日:2008-08-06
标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
发明人：BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER
权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.