CAS: 17016-83-0; (S)-4-Isopropyl-2-Oxazolidinone

相似化合物

95530-58-8 103723-70-2 54705-42-9

上下游产品

CAS号2026-48-4 L-缬氨醇 | CAS号124-38-9 二氧化碳 | CAS号105-58-8 碳酸二乙酯 | CAS号201230-82-2 carbon monoxide | CAS号599164-44-0 (S)-N-[(3R)-3-m... | CAS号84272-19-5 (4S)-(-)-4-ISOP... | CAS号80697-99-0 (S)-3-((R)-3-(b... | CAS号67-56-1 甲醇 | CAS号186355-83-9 (4S)-3-(2-bromo... | CAS号192329-12-7 (4S)-3-(2-cyclo... | CAS号17016-83-0 (4S)-(-)异丙基-2-恶唑酮 | CAS号95530-58-8 (4R)-(+)-4-异丙基-... | CAS号80697-93-4 (S)-4-(1-Isopro... | CAS号77877-19-1 (|S|)-(+)-4-异丙基... | CAS号16369-05-4 2-氨基-3-甲基-1-丁醇 | CAS号2026-48-4 L-缬氨醇 | CAS号77887-48-0 (N-乙酰基)-(4s)-异丙... | CAS号90719-29-2 (4S)-N-巴豆酰基-4-异...

L-缬氨酸置于sodium Tetrahydroborate,碘,Potassium Carbonate体系中,用 四氢呋喃 用作溶剂,化学反应 30.5H,反应生成(S)-4-异丙基-2-唑烷酮
参考文献:海洋大环内酯lytophilippine A的非对映异构体的合成
标题:海洋大环内酯lytophilippine A的非对映异构体的合成
摘要:冻干品a的非对映异构体的合成需要使用已知构件的22个最长的线性步骤.交叉复分解/不对称醛醇加成和区域选择性酯化/闭环复分解是构建支架的有效组合工具.在不同溶剂(系统)中进行的详细NMR研究为名为lytophilippine A的分子的根深蒂固的构型错配提供了证据.
Doi:10.1021/acs.Orglett.9B00722

专利信息

专利号:US-6350878-B1
优先权日:1998-05-18
标 题 :Intermediates for the synthesis of epothilones and methods for their preparation
发明人：ALTMANN KARL-HEINZ; BAUER ARMIN; SCHINZER DIETER
权利人:NOVARTIS AG
摘要:The invention relates to a method of synthesis for a compound of formula (I),wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.

专利号:US-6849743-B2
优先权日:1997-08-15
标 题 :Synthesis of clasto-lactacystin β-lactone and analogs thereof
发明人：SOUCY FRANCOIS; FLAMONDON LOUIS; BEHNKE MARK; ROUSH WILLIAM
权利人:MILLENNIUM PHARM INC
摘要:The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

专利号:US-6887887-B2
优先权日:2001-03-19
标 题:Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor
发明人：BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER; SCHEINBERG DAVID
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: n n nwhere R 1 is an optionally substituted or halogenated alkyl, aryl, heteroalkyl or heteroaryl amine, said R 1 further comprising a cyclic or bicyclic structure; R 2 is methyl, CH 2 CH 3 , (CH 2 ) 2 CH 3 , C(CH 3 ) 3 , phenyl, 3,4-dichlorophenyl, biphenyl, benzyl, 4-hydroxybenzyl, piperidine, N-Boc-4-piperidine, CH 2 -(N-Boc-4-piperidine), 4-tetrahydropyran, CH 2 -4-tetrahydropyran, 3-methyl indolyl, 2-naphthyl, 3-pyridyl, 4-pyridyl, 3-thienyl; R 3 is R 2 or C 3-8 alkyl, R 4 is C 1-3 alkyl; and R 5 is NH 2 , OH, NHOH, NHOCH 3 , N(CH 3 )OH, N(CH 3 )OCH 3 , NHCH 2 CH 3 , NH(CH 2 CH 3 ), NHCH 2 (2,4-(OCH3) 2 Ph, NHCH 2 (4-NO 2 )Ph, NHN(CH 3 ) 2 , proline, or 2-hydroxymethyl pyrrolidine. Additionally, a method for the treatment of a neoplastic disease or for the inhibition of tumor cell growth each comprising the step of administering to an individual in need of such treatment a pharmacologically effective dose of the compounds of the present invention are provided.

专利号:US-5403937-A
优先权日:1993-04-30
标 题 :Process for preparing intermediates for the synthesis of antifungal agents
发明人：SAKSENA ANIL K; GIRIJAVALLABHAN VIYYOOR M; PIKE RUSSELL E; WANG HAIYAN; LOVEY RAYMOND G; LIU YI-TSUNG; GANGULY ASHIT K; MORGAN WILLIAM B; ZAKS ALEKSEY
权利人:SCHERING CORP
摘要:Disclosed is a process for preparing chiral compounds of the formula (I) (I) wherein: X1 and X2 are independently F or Cl; and E is -SO2R2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula or wherein: X1 and X2 are independently F or Cl; B represents -C(O)Q* or -CH2OR''; Q* represents a chiral auxiliary group; R'' represents a hydroxy protecting group selected from -CH2C6H5, or -C(O)R1, wherein R1 is C1-C6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.

专利号:US-5668164-A
优先权日:1996-07-12
标 题:Process for synthesis of chiral cis-and trans-3-amino-4 substituted pyrrolidine compounds
发明人：MA ZHENKUN; COOPER CURT S; FUNG ANTHONY K L; CHU DANIEL T
权利人:ABBOTT LAB
摘要:Process for preparation of chiral cis-3,4-substituted pyrrolidine compounds having the formulas: ##STR1## and chiral 3,4-trans-substituted pyrrolidine compounds having the formulas: ##STR2## with the assistance of a streochemically directing chiral oxazolidinone moiety having the formula: ##STR3## wherein P, R and R 1 are specifically defined, by sequential reaction of the compound or subsequent intermediates with an a,b-unsaturated add chloride, reaction with N-benzyl-N-(methoxymethyl)trimethyl-silylmethylamine and separating isomers by chromatography, hydrolytic removal of the oxazolidinone moiety, reaction with diphenylphosphoryl azide and triethylamine, and debenzylating; and novel intermediates of the process.

专利号:US-9845299-B2
优先权日:2013-01-14
标 题 :Process for the preparation of a fluorolacton derivative
发明人：CHEN RONGMIN; LI YUANQIANG; ZHAO JIANQIANG; ZHENG JIANBING; ZHU GUOLIANG
权利人:GILEAD PHARMASSET LLC
摘要:A novel process for the preparation of a fluorolactone derivative of the formula n n n n n n n n n n n n and of its acylated derivative of formula n n n n n n n n n n n n n n n n wherein R 1 stands for a hydroxy protecting group is described. n n n n n The acylated fluor lactones of formula V, particularly the benzoyl derivative with R 1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.