CAS: 17083-85-1; Tetraethylammonium Borohydride

专利信息

专利号:US-2024239791-A1
优先权日:2021-04-26
标题 :Processes for the synthesis of valbenazine
发明人：TUCKER JOHN LLOYD
权利人:NEUROCRINE BIOSCIENCES INC
摘要:The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

专利号:US-2022363680-A1
优先权日:2019-09-13
标题 :Processes for the synthesis of valbenazine
发明人：TUCKER JOHN; KUCERA DAVID; HETTINGER DONALD; COCHRAN BRIAN M; BRANUM SHAWN; LE JACKIE; MCGEE KEVIN
权利人:NEUROCRINE BIOSCIENCES INC
摘要:The present application relates to processes for making (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b -hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl (S)-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

专利号:US-7524477-B2
优先权日:2004-02-02
标题:Method of production of B10H102− ammonium salts and methods of production of B18H22
发明人：SPIELVOGEL BERNARD; COOK KEVIN
权利人:SEMEQUIP INC
摘要:The invention provides new methods for synthesis of B 9 H 9 − , B 10 H 10 2− , B 11 H 14 − , and B 12 H 12 2− salts, particularly alkylammonium salts of B 9 H 9 − , B 10 H 10 2− , B 11 H 14 − , and B 12 H 12 2− . More particularly, the invention provides methods of preparing tetraalkylamronium salts of B 9 H 9 − , B 10 H 10 2− , B 11 H 14 − , and B 12 H 12 2− by pyrolysis of tetraalkylammonium borohydrides under controlled conditions. The invention additionally provides methods of preparing, in an atom efficient process, octadecaborane from the tetraalkylammonium salts of the invention. Preferred methods of the invention are suitable for preparation of isotopically enriched boranes, particularly isotopically enriched 10 B 18 H 22 and 11 B 18 H 22 .

专利号:US-2024229131-A1
优先权日:2022-12-22
标 题 :Transition-metal catalyst compositions and methods for sequencing by synthesis
发明人：MARIANI ANGELICA; BEECH TIMOTHY; FRANCAIS ANTOINE; PANIGRAHI ADYASHA; HATTINGH KATHRYN; CRESSINA ELENA
权利人:ILLUMINA INC
摘要:The present application relates to compositions and methods for sequencing by synthesis. A blocking group of a nucleotide may be removed by a transition metal catalyst, the transition metal catalyst activated by a non-reducing ligand and a reducing agent.

专利号:US-2024247311-A1
优先权日:2022-12-22
标题 :Palladium catalyst compositions and methods for sequencing by synthesis
发明人：PEDROSO CASSIO; PANIGRAHI ADYASHA; MARIANI ANGELICA; CARVER ADAM; HOURS RAPHAËLLE; CHANDRACHUD PREETI; FRANCAIS ANTOINE; APSUNDE TUSHAR; HATTINGH KATHRYN; BEECH TIMOTHY; SOLIS DANIEL; LAWRENCE ELLIOT J
权利人:ILLUMINA INC
摘要:The present application relates to palladium catalyst composition and uses in sequencing by synthesis. In particular, the Pd catalyst composition comprises one or more macrocycles (e.g., cyclodextrin or analogs thereof) as additives for improving thermal or oxidative stability of the active Pd(0) species.

专利号:US-2024218443-A1
优先权日:2021-05-20
标 题:Methods of sequencing using 3' blocked nucleotides
发明人：MARIANI ANGELICA; FRANCAIS ANTOINE; TOPPING FREDERICK JAMES; WINNARD CHRISTOPHER; BALDING PHILIP; YUN CHOL STEVEN; IAVICOLI PATRIZIA; HATTINGH KATHRYN; WU XIAOLIN; LIU XIAOHAI
权利人:ILLUMINA INC
摘要:The present application relates to palladium compositions, methods for sequencing by synthesis using nucleotides with 3′ blocking groups, and sequencing kits, where one or more palladium scavengers were used to improve sequencing metrics such phasing and prephasing values.