溴丙酮置于lithium Aluminium Tetrahydride体系中,用15%的收率获得溶剂紫36 参考文献:Catalytic Asymmetric Cyclization Of Some Bromohydrins With Chiral Cobalt Complex 标题:Catalytic Asymmetric Cyclization Of Some Bromohydrins With Chiral Cobalt Complex 摘要:在存在光学活性的钴(Salen)型复杂物的情况下,研究了多种溴醇与碱的非对称环化反应.获得了光学纯度适中的光学活性环氧烷.赤霉-3-溴-2-丁醇和反霉-3-溴-2-丁醇进行了类似的环化,分别仅获得了反-2,3-二甲基环氧烷和顺-2,3-二甲基环氧烷,这表明溴醇的环化过程通过完全的sn2型反应进行. Doi:10.1246/bcsj.61.603
专利号:US-12441721-B2 优先权日:2020-07-21 标 题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols 发明人:KARPOORMATH RAJSHEKHAR; SAYYAD NISAR 权利人:UNIV OF KWAZULU NATAL 摘要:The invention provides for methods for the synthesis of various compounds through reaction of carboxamide, or carboxamide derivatives, with various substituted or unsubstituted haloalkanols in a one-step, single vessel, reaction mechanism. Preferably, but not exclusively, the reaction proceeds in the absence of any solvents, catalyst, base, or any further reagents.
专利号:US-4226778-A 优先权日:1978-04-14 标 题:Process for the manufacture of alkylene carbonates 发明人:VENTURELLO CARLO; D ALOISIO RINO 权利人:MONTEDISON SPA 摘要:A new process is disclosed for the synthesis of alkylene carbonates having from 2 to 4 carbon atoms in the chain, starting from a corresponding halohydrin having the formula: wherein Ra, Rb, Rc and Rd are independently hydrogen or alkyl, aryl, alkylaryl or arylalkyl radicals and where X is a halogen, characterized in that said halohydrin is reacted with a bicarbonate of a quaternary -onium compound, where '-onium' means ammonium, phosphonium, arsonium or stibonium, preferably using an organic solvent as diluent and operating in the presence of carbon dioxide.
专利号:US-2012328569-A1 优先权日:2010-03-02 标题:Inhibitors of hepatitis c virus ns5b polymerase 发明人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN 权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN 摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-9834536-B2 优先权日:2013-04-23 标题:Method for producing catalyst for cyclic carbonate synthesis 发明人:TAKAHASHI TOSHIKAZU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU; YAMAMOTO SHOUJI; NANIKI TAKASHI; FURUKAWA TAKURO 权利人:AIST; MARUZEN PETROCHEM CO LTD 摘要:A method for producing a heterogeneous catalyst for use of synthesizing cyclic carbonates by reacting an epoxide and carbon dioxide in the presence of the catalyst. A method for making a catalyst that includes forming a catalyst precursor then reacting the catalyst precursor with a tertiary phosphine.
专利号:US-2023295139-A1 优先权日:2020-07-21 标题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols
[参考文献]: Karla M S Gonalves, Et Al. Conformational Analysis Of 1-Chloro- And 1-Bromo-2-Propanol. J Phys Chem A. 2013 Oct 24;117(42):10980-4.
合成参考文献
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