CAS: 399-97-3; 2-Amino-4-Fluorophenol

该化合物是一种氟芳烃化合物,由氨基和羟基功能组组成,使其成为有机合成的多功能中间体,其分子结构(C6H6FNO)允许选择性反应,特别是在制药和农用化学应用中.氟代用可增强代谢稳定性和生物活性分子的结合性,而氨基和氢氧基组则有利于进一步的衍生.该化合物通常用于染料,离心机和环流框架的合成.高纯度能确保敏感反应的性能一致.适当处理建议由于对光和氧化的潜在敏感性.建议在惰性条件下进行储存以保持稳定性.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号394-33-2 4-氟-2-硝基苯酚 | CAS号109-60-4 醋酸正丙酯 | CAS号371-41-5 4-氟苯酚 | CAS号398-63-0 6-氟-2H-1,4-苯并噁唑... | CAS号220120-59-2 6-氟-3,4-二氢-2H-1... | CAS号701-16-6 5-氟-2-甲基苯并恶唑 | CAS号105655-00-3 6-氟-3,4-二氢-2h-苯... | CAS号13451-79-1 5-氟苯并恶唑-2-酮 | CAS号13451-78-0 5-氟苯并噁唑-2-硫醇 | CAS号1682-39-9 2-氨基-5-氟苯并恶唑 | CAS号135533-78-7 2-氯-5-氟苯并恶唑 | CAS号93794-14-0 3-[amino-(5-flu...

合成工艺路线路线简述

    4-氟苯酚置于sodium Tetrahydroborate,10% Palladium On Activated Carbon,四丁基溴化铵,硝酸体系中,用 甲醇,水,1,2-二氯乙烷 用作溶剂,化学反应 6.0H,反应生成2-氨基-4-氟苯酚
    参考文献:四齿双氨基酚盐配体的铁(II)配合物:合成与表征,溶液行为和与o 2的反应性
    标题:四齿双氨基酚盐配体的铁(II)配合物:合成与表征,溶液行为和与o 2的反应性
    摘要:四齿双(氨基酚盐)配体h 2 Salan X和h 2 Bapen X(其中x表示对酚盐取代基= H,Me,F,Cl)与[fe {n(sime 3)2 } 2 ]反应形成铁(II)配合物,可以在存在合适的供体配体l(l =吡啶或thf)的情况下分离为配合物[fe(salan X)(l)2 ]和[fe(bapen X)(l)2 ].在没有供体配体的情况下,可以是单核络合物,例如[fe(salan T Bu,T Bu)],也可以是[fe(salan)x)] 2.通过vt 1 H和19 F NMR光谱研究了[fe(salan F)(l)2 ]和[fe(bapen F)(l)2 ]配合物在溶液中的动态配位行为,揭示了它们之间的平衡.具有不同配体配位拓扑结构的顺式异构体,顺式-α,顺式-β和反式.铁(II)salan X络合物暴露于o 2导致形成[{fe(salan X)} 2(μ-O)]或[{fe(salan)x)(l)}
    Doi:10.1021/ic1016998

    海关参考信息

    专利信息


    专利号:US-7247749-B2
    优先权日:2003-01-29
    标 题:Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions
    发明人:AUFDERMARSH CARL A; AMIN HARSHAD P; LOGOTHETIS ANESTIS; GUBANOV VICTOR; VOLKOVA MARGARITA; KARMANOVA LIOUDMILA; KOLLAR ALEXANDR; TROICHANSKAIA POLINA; EMELIANOV GENNADY; BERENBLIT VSEVOLOD
    权利人:FED STATE UNITARY ENTPR S V LE
    摘要:Novel monoamidine, monoamidoxime and bisamidine curatives, co-curatives and cure accelerators are provided for use with perfluoroelastomeric compositions as well as novel synthesis methods for making monoamidine- and monoamidoxime-based curatives, co-curatives and cure accelerators. Also provided are diphenyl-based curatives, co-curatives and cure accelerators having sufficiently high molecular weight such that the melting temperature of the curatives, co-curatives and cure accelerators is no greater than about 240° C., and more preferably no greater than about 230° C.

    专利号:EP-4428132-A1
    优先权日:2023-03-08
    标题:Slack-activating compounds and their medical use
    发明人:SCHMIDTKO ACHIM; PROSCHAK EUGEN; BALZULAT ANNIKA; ZHU WENXIN; FLAUAUS CATHRIN; STEINHILBER DIETER; LU RUIRUI; HERNANDEZ OLMOS VICTOR; HEERING JAN
    权利人:JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN
    摘要:The present invention pertains to novel compounds and their synthesis which are structurally derived from 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[ b , f ][1,4]oxazepine. The compounds of the invention were shown in a comparative study to bind and activate potassium channels, in particular Slack. Based on their activating activity, the compounds of the invention and pharmaceutical compositions containing them can be used in various therapeutic applications for the treatment or prevention of pathologies.

    专利号:CN-119241459-A
    优先权日:2024-09-03
    标题:Benzo (A) benzo (B) benzo (A oxazole/benzo Synthesis method of thiazole compound

    专利号:US-7521510-B2
    优先权日:2003-01-29
    标 题 :Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions
    发明人:AUFDERMARSH CARL A; AMIN HARSHAD P; LOGOTHETIS ANESTIS
    权利人:GREENE TWEED INC
    摘要:Novel monoamidine, monoamidoxime and bisamidine curatives, co-curatives and cure accelerators are provided for use with perfluoroelastomeric compositions as well as novel synthesis methods for making monoamidine- and monoamidoxime-based curatives, co-curatives and cure accelerators. Also provided are diphenyl-based curatives, co-curatives and cure accelerators having sufficiently high molecular weight such that the melting temperature of the curatives, co-curatives and cure accelerators is no greater than about 240° C., and more preferably no greater than about 230° C.
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    合成参考文献


    参考文献:10.1007/s42114-024-01119-7
    摘要:Tang L, Hu Q, Pan X, Lei Y, Li L, Wang Y, Zhou W, Liu J, Zhang J, Liu X. Surface modification of PBO fibers with random copolymer containing benzoxazole for improving surface activity, and enhancing interfacial bonding strength with cyanate ester resins. Adv Compos Hybrid Mater. 2024 Dec 12;8(1). doi: 10.1007/s42114-024-01119-7.
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