CAS: 4146-30-9; (2S,3S,4R,5R,6R)-5-Amino-2-(Aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-Diamino-2-(((2R,3R,4R,5S,6R)-3-Amino-6-(Aminomethyl)-4,5-Dihydroxytetrahydro-2H-Pyran-2-yl)Oxy)-6-Hydroxycyclohexyl)Oxy)-4-Hydroxy-2-(Hydroxymethyl)Tetrahydrofuran-3-yl)Ox
该化合物是一种来自细菌* 红外菌* 的微粒球菌抗生素,主要用于抗菌特性,特别是抗克氏阴性细菌;该物质的特点是结构复杂,包括多种氨基糖,与氨基环环环相连.新辛基乙硫酸盐在水中溶解性很强,适合各种药方,包括时下和眼科应用.它展示了广泛的活动,特别是用于抗菌性,特别是抗菌性,特别是抗菌性抗菌和抗性肺炎.但是,由于潜在的...
- 英文名称(2S,3S,4R,5R,6R)-5-Amino-2-(Aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-Diamino-2-(((2R,3R,4R,5S,6R)-3-Amino-6-(Aminomethyl)-4,5-Dihydroxytetrahydro-2H-Pyran-2-yl)Oxy)-6-Hydroxycyclohexyl)Oxy)-4-Hydroxy-2-(Hydroxymethyl)Tetrahydrofuran-3-yl)Ox
- 中文名称新霉素B硫酸盐
- IUPAC名称(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol tris(sulfate)
- 其它别名Framycetin Sulfate; Neomycinbsulfate; D-Streptamine, O-2,6-Diamino-2,6-Dideoxy-.Beta.-L-Idopyranosyl-(1?3)-O-.Beta.-D-Ribofuranosyl-(1?5)-O-2,6-Diamino-2,6-Dideoxy-.Alpha.-D-Glucopyranosyl-(1?4)-2-Deoxy-, Sulfate (1:3) (Salt); Neomycin B Trisulfate; Neomycin Sulphate B(Framycetin Sulphate); Neomycin Sulphate B; (2R,3S,4R,5R,6R)-5-Amino-2-(Aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-Diamino-2-[(2R,3R,4S,5R)-4-[(2S,3S,4S,5R,6R)-3-Amino-6-(Aminomethyl)-4,5-Dihydroxy-Oxan-2-Yl]Oxy-3-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Oxy-3-Hydroxy-Cyclohexyl]Oxy-Oxane-3,4-Diol Sulphate; Framycetin Sulphate
- CAS编号4146-30-9
- MFCD编号:MFCD00144873
- EINECS号:223-969-3
- FDA UNII编号:Y3720KZ4TQ
- 分子式:C23H52N6O25S3
- 分子量:908.89
- 产品CID: 1428910
- 同类组份化合物CAS55298-68-5 (palmitate)1406-04-8 (undecylenate)119-04-0 (free base)1405-10-3 (sulfate)4146-30-9 (B sulfate)
- 产品分类原料药 → 抗生素类药物 → 氨基糖苷类药
物理性质
- 熔点>160°C (分解)
- 沸点927.1 °C at 760 mmHg
- 闪点514.5 °C
- PSA:436.09
- LogP:-3.655 (est)
- 蒸汽压0 mmHg at 25 °C
- 溶解性Freely Soluble In Water, Very Slightly Soluble In Alcohol, Practically Insoluble In Acetone.
- 外观形态白色至类白色固体
- 储存条件防潮, -20°C 冰箱, 在惰性气其中
- 产品应用该化合物是一种在体外和体外有强力抗菌活性的小动物,它与细菌30S 脊髓炎亚细胞结合,抑制蛋白合成并导致对 MRNA的错误解读. 尼小霉素展示了针对克-阴性和某些克-阳性细菌的广泛频谱活动,其中微细胞值通常取决于生物体的低微摩尔范围(~0.5-10 微米).在细胞实验中,它有效地抑制了细菌的生长和生存能力. 在体内,新霉素显示出很强的抗菌功效,减少了感染模型中的细菌负担,尽管系统使用受到毒性的限制.这些数据支持新微菌作为一种精细的抗生素,用于研究抗菌抑制和抗微生物机制.
MSDS等安全信息
- GHS象形图
- GHS符号GHS08;
注释: Health hazard - 危险类别生殖毒性 类别2
特定目标器官毒性-重复接触 类别2
急性毒性 类别4(吸入)
急性毒性 类别4(经口)
皮肤腐蚀/刺激 类别2
皮肤致敏 类别1
急性毒性 类别4(经皮) - 警示词Warning(警告)
- 危险描述H361 |怀疑对生育能力或胎儿造成损害.
H373 |长期或反复接触可能损害器官.
H332 |吸入有害.
H302 |吞咽有害.
H315 |造成皮肤刺激.
H317 |可能引起皮肤过敏反应.
H312 |皮肤接触有害. - 防范说明P201-P202-P281-P308+P313-P405-P501-P260-P314-P501
- UN编号2811
- 危险品标志Xi
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号2037-48-1 2-脱氧链胺,二氢溴化物 | CAS号84107-26-6 (1S,3R,4S,6R)-4...合成工艺路线路线简述
专利信息
专利号:US-2018105546-A1
优先权日:2011-06-14
标题:Methods for Chemical Synthesis of Biologically Active Compounds Using Supramolecular Protective Groups and Novel Compounds Obtainable Thereby
专利号:US-2014243280-A1
优先权日:2011-06-14
标题:Methods for chemical synthesis of biologically active compounds using supramolecular protective groups and novel compounds obtainable Thereby
专利号:PL-212211-B1
优先权日:2000-06-02
标题:A composition for the production of scintigraphic imaging agent, a composition for scintographic imaging, a method for the synthesis of a radionuclide-labeled conjugate of ethylenedicysteine with a homing ligand for imaging, the use of a composition containing a radionklid labeled conjugate of ethylene-distysteine with a homogeneous ligand for the production of pharmaceutical agents for radiopharmaceutical preparation or a preparation of a cancer preparation
专利号:EP-2721046-A1
优先权日:2011-06-14
标题:Methods for chemical synthesis of biologically active compounds using supramolecular protective groups and novel compounds obtainable thereby
专利号:WO-2012173477-A1
优先权日:2011-06-14
标题 :Methods for chemical synthesis of biologically active compounds using supramolecular protective groups and novel compounds obtainable thereby
专利号:EP-2721046-B1
优先权日:2011-06-14
标题 :Methods for chemical synthesis of biologically active compounds using supramolecular protective groups and novel compounds obtainable thereby
发明人：HERRMANN ANDREAS; BASTIAN ANDREAS ALEXANDER; MARCOZZI ALESSIO
权利人:UNIV GRONINGEN
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合成参考文献
参考文献:10.1007/bf01975116
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参考文献:10.1007/bf00123400
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参考文献:10.1385/1-59259-986-9:187
摘要:Cawood ML. Measurement of plasma renin activity. Methods Mol Biol. 2006;324():187–96. doi: 10.1385/1-59259-986-9:187.
参考文献:10.1007/978-1-59745-182-6_20
摘要:Lin Y, Molter J, Lee Z, Gerson SL. Bioluminescence imaging of hematopoietic stem cell repopulation in murine models. Methods Mol Biol. 2008;430():295–306. doi: 10.1007/978-1-59745-182-6_20.
参考文献:10.1007/s10886-014-0448-7
摘要:Vadassery J, Reichelt M, Jimenez-Aleman GH, Boland W, Mithöfer A. Neomycin Inhibition of (+)-7-Iso-Jasmonoyl-L-Isoleucine Accumulation and Signaling. Journal of Chemical Ecology. 2014 May 25;40(7):676–86. doi: 10.1007/s10886-014-0448-7.
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