CAS: 446-30-0; 4-Chloro-2-Fluorobenzoic Acid

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CAS号452-75-5 2-氟-4-氯甲苯 | CAS号56456-49-6 4-氯-2-氟苄醇 | CAS号394-39-8 2-氟-4-氯苯甲酰氯 | CAS号56447-54-2 4-氯-5-氯磺酰基-2-氟苯甲酸 | CAS号4793-22-0 4-氯-2-氟-5-氨磺酰苯甲酸 | CAS号625-98-9 间氯氟苯 | CAS号71916-82-0 4-氯-2-氟苄溴 | CAS号57946-56-2 4-氯-2-氟苯胺 | CAS号57381-51-8 4-氯-2-氟苯甲腈 | CAS号198967-23-6 4-氯-2-氟-N-甲氧基-N-甲基苯胺 | CAS号73129-12-1 4-Chloro-2-fluo...

4'-氯-2'-氟苯乙酮置于copper(II) Nitrate Trihydrate,氧气体系中,用 乙腈 作为反应溶剂,180.0 °C,2.5 Mpa 条件下,反应 1.5H,以77%的收率获得产物4-氯-2-氟苯甲酸
参考文献:取代苯甲酸类有机物的连续化合成方法
标题:取代苯甲酸类有机物的连续化合成方法
摘要:本发明提供了一种取代苯甲酸类有机物的连续化合成方法.该连续化合成方法包括:在催化剂和有机溶剂的存在下,将式(ⅰ)所示的有机物与氧气连续地输入连续化反应装置进行连续氧化反应,得到取代苯甲酸类有机物,并连续排出,取代苯甲酸类有机物具有式(ⅱ)所示结构.氧气为绿色试剂,且廉价易得,反应结束后不会产生大量的三废,体系易处理.使用连续化反应操作能够降低高浓度氧在批次反应中使溶剂闪蒸爆炸的风险.在同等氧化条件中,采用连续化制备工艺能够减少了氧气的逃逸,使氧气利用率大大增加,也简化了操作,提高了反应的安全性和取代苯甲酸类有机物的收率.

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:US-2025059149-A1
优先权日:2023-07-05
标题 :Microreactor and method for continuous flow synthesis of 2,5-furandicarboxylic acid
发明人：YU CHAO; HE JIALUN; CHEN XIAO; LI YINGGUO; JIANG DANFENG
权利人:UNIV JIANGSU SCIENCE & TECH
摘要:Disclosed is a microreactor for continuous flow synthesis of 2,5-furandicarboxylic acid, the microreactor includes a first container, a collection device, an injection pump, a first flow pump, a second flow pump, a first microreactor substrate, ion exchange resin adsorption pipes, activated carbon adsorption pipes, a second microreactor substrate, an oxygen source, a first T-connector, a second T-connector, and a third T-connector; where the first container is connected to the first T-connector via the first flow pump, the injection pump is connected to the first T-connector, the third T-connector is connected to the first T-connector and the first microreactor substrate, respectively, the first microreactor substrate is connected to the ion exchange resin adsorption pipes, the activated carbon adsorption pipes, the second T-connector, and the second microreactor substrate in sequence, and the oxygen source is connected to the second T-connector. Further disclosed is a method for continuous flow synthesis of 2,5-furandicarboxylic acid.

专利号:EP-4421075-A1
优先权日:2023-02-27
标 题 :Process for the preparation of venetoclax and intermediates used therein
发明人：BERGANT SIMONCIC ANA
权利人:KRKA D D NOVO MESTO
摘要:The invention relates to a process for the synthesis of Venetoclax. The invention further relates to intermediates that are useful in the synthesis of Venetoclax.

专利号:WO-9519967-A1
优先权日:1994-01-21
标 题:A process for the preparation of 3-(substituted phenyl) pyrazole derivatives
发明人：BANSAL HARJINDER SINGH; BARNETT SUSAN PATRICIA; CHRYSTAL EWAN JAMES TURNER; ROGERS MICHAEL LOUIS
权利人:ZENECA LTD; BANSAL HARJINDER SINGH; BARNETT SUSAN PATRICIA; CHRYSTAL EWAN JAMES TURNER; ROGERS MICHAEL LOUIS
摘要:A process for the synthesis of a herbicide of general formula (I), wherein X is halogen or cyano; Y is H, alkyl, alkenyl or alkynyl, any of which may optionally be substituted, cyano, nitro, halogen, NR?10R11, OR10, SO¿pR10, CO2R?10, CONR10R11, NR10SO¿2R?11, COR10, C(NOR10)R11, OSO¿pR?10 or NR10COR11; R1¿ is hydrogen or alkyl, alkenyl, alkynyl, benzyl, cycloalkyl or cycloalkenyl, any of which may optionally be substituted; R2 is lower haloalkoxy; and R3 is halogen; from a compound of general formula (II), wherein X and Y are as defined above and R4 is lower alkyl; comprises the steps of: (i) reacting the compound of formula (II) with a hydrazine derivative; (ii) reacting the product with a compound R9-Z where R9 is a lower haloalkyl group and Z is a leaving group in the presence of a base; and (iii) halogenating the product to give a compound of formula (I).

专利号:WO-2020248279-A1
优先权日:2019-06-14
标 题 :Continuous synthesis method for substituted benzoate organic matter
发明人：HONG HAO; LU JIANGPING; ZHANG ENXUAN; LIU ZHIQING; LI CHAO
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a continuous synthesis method for a substituted benzoate organic matter. The continuous synthesis method comprises: in the presence of a catalyst and an organic solvent, continuously feeding an organic matter as represented by formula (I) and oxygen into a continuous reaction device for continuous oxidation reaction to obtain a substituted benzoate organic matter, and performing continuous discharge, wherein the substituted benzoate organic matter has a structure as represented by formula (II). Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters.

专利号:CN-118666668-A
优先权日:2024-06-11
标题:Clinical study on the synthesis of 4,5-dichloro-2-fluorobenzoic acid, a synthetic building block for pain medication