CAS: 52705-93-8; (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-Hydroxy-4,4,8,10,14-Pentamethyl-17-((S)-6-Methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Hept-5-En-2-yl)Hexadecahydro-

上下游产品

CAS号88140-39-0 6''-malonylgins... | CAS号88140-37-8 malonyl ginseno... | CAS号88140-34-5 malonylginsenos... | CAS号88140-38-9 6''-malonylgins...

人参皂甙置于水体系中,化学反应 6.0H,反应生成 人参皂苷rd
参考文献:Biotransformation Of The Principal Ginsenosides Of Panax Ginseng Into Minor Glycosides Through The Action Of Bacterium Paenibacillus Sp. Bg134
标题:Biotransformation Of The Principal Ginsenosides Of Panax Ginseng Into Minor Glycosides Through The Action Of Bacterium Paenibacillus Sp. Bg134
摘要:细菌 Paenibacillus Sp. Bg134 能够将主要的 20(S)-原人参二醇皂苷 Rc,Rb2,Rd 和 Rb1 生物转化为相应的次要糖苷 C-Mc1,C-O 和 F-2.与其他几种微生物相比,Paenibacillus Sp. Bg134 的特异性在于它只切割其碳水化合物组分中的末端 C-3 和 C-20 β-D-葡萄糖.
DOI:10.1007/s10600-014-1054-1

专利信息

专利号:US-9976167-B2
优先权日:2012-12-06
标题:Group of glycosyltransferases and use thereof
发明人：ZHOU ZHIHUA; YAN XING; FAN YUN; WANG PINGPING; WEI YONGJUN; WEI WEI; ZHANG JUN
权利人:SHANGHAI INST BIOLOGICAL SCIENCES CAS
摘要:Provided are the use of glycosyltransferases gGT25, gGT13, gGT30, gGT25-1, gGT25-3, gGT25-5, gGT29, gGT29-3, gGT29-4, gGT29-5, gGT29-6, gGT29-7, 3GT1, 3GT2, 3GT3, 3GT4 and derived polypeptides therefrom in the catalyzed glycosylation of terpenoid compounds and the synthesis of new saponins, wherein the glycosyltransferases can specifically and efficiently catalyze tetracyclic triterpenoid compound substrates at positions C-20 and/or C-6 and/or C-3 during hydroxyl glycosylation, and/or transfer the glycosyl from a glycosyl donor to the first glycosyl of the tetracyclic triterpenoid compounds at position C-3, so as to extend the sugar chain. The glycosyltransferases can also be used for constructing man-made synthetic rare ginsenosides and a variety of new ginsenosides and derivatives thereof.

专利号:US-11629162-B2
优先权日:2015-12-17
标 题:Triterpene saponin variants, methods of synthesis and use thereof
发明人：TAN DEREK S; GIN DAVID Y; WALKOWICZ WILLIAM E; FERNANDEZ-TEJADA ALBERTO; RAGUPATHI GOVINDASWAMI
权利人:MEMORIAL SLOAN KETTERING CANCER CENTER
摘要:A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.

专利号:EP-3357931-B1
优先权日:2008-04-08
标 题:Methods of synthesis of triterpene prosapogenins and triterpene saponins

专利号:EP-3357931-A1
优先权日:2008-04-08
标 题 :Methods of synthesis of triterpene prosapogenins and triterpene saponins

专利号:US-9718850-B2
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis and uses thereof
发明人：GIN DAVID; ADAMS MICHELLE; DENG KAI; LIVINGSTON PHILIP; RAGUPATHI GOVINDASWAMI; CHEA ERIC; FERNANDEZ-TEJADA ALBERTO; NORDSTROEM LARS ULRIK; Walkowicz William; GARDNER JEFFREY; TAN DEREK
权利人:MEMORIAL SLOAN-KETTERING INST FOR CANCER RES
摘要:The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

专利号:CN-114480323-A
优先权日:2020-11-11
标 题:Avena Glycosyltransferase AsUGT73E1 and Its Application in the Synthesis of Steroidal Saponins