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三甲基膦酰基乙酸酯,Potassium Tert-Butylate 以 2-Methf 作为反应溶剂,化学反应生成 二甲氧基膦酰基乙酸叔丁酯
参考文献: Carbamoyl Compounds As Dgat1 Inhibitors 190[fr] Composés Carbamoyles Comme Inhibiteurs De Dgat1 190
标题: Carbamoyl Compounds As Dgat1 Inhibitors 190[fr] Composés Carbamoyles Comme Inhibiteurs De Dgat1 190
摘要:Dgat-1抑制剂化合物公式(I),药用可接受的盐和前药,以及药物组合物,制造它们的过程以及它们在治疗例如肥胖症中的用途,其中,例如,环a是可选取代的2,6-吡嗪二基;x是=o;环b是可选取代的1,4-苯基;y1是直接键或-O-;y2是-(Ch2)R-,其中r是2或3;n是0或当y1是环b和环c之间的直接键并且当环b是1,4-苯基和环c是(4-6C)环烷时,N是1;环c是可选取代的(4-6C)环烷,(7-10C)双环烷,(8-12C)三环烷,苯基或吡啶二基;l是直接键或-O-;p是0,1或2,并且当p是1或2时,Ra1和ra2各自独立地为氢或(1-4C)烷基;z是羧酸或其模拟物或生物等排体.

专利信息

专利号:US-6413955-B1
优先权日:1999-10-04
标 题:Integrin receptor antagonists
发明人：ASKEW BEN C; SMITH GARRY R
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.

专利号:CN-119306608-A
优先权日:2023-07-14
标题 :Milobalin intermediate chiral synthesis method of body