CAS: 66701-25-5; (2S,3S)-3-(((S)-1-((4-Guanidinobutyl)Amino)-4-Methyl-1-Oxopentan-2-yl)Carbamoyl)Oxirane-2-Carboxylic Acid

专利信息

专利号:US-2006154325-A1
优先权日:2005-01-10
标题 :Synthesis of epoxide based inhibitors of cysteine proteases
发明人：BOGYO MATTHEW; VERHELST STEVEN H
权利人:BOGYO MATTHEW; VERHELST STEVEN H
摘要:Epoxide based cysteine protease inhibitors containing peptide derivatives and methods for synthesizing them in sold phase are disclosed. Preferably, an epoxy succinyl “warheadâ€? (for binding to the enzyme) is prepared, having two amino acid residues or residue-like structures on either side. Natural and non-natural amino acids may be used. The present process may be carried out entirely on a solid support, with the proviso that a dipeptide like group is prepared prior to coupling to one side of the supported complex. The method lends itself to more efficient inhibitor synthesis, and may be employed with mixtures of peptide compounds, and various modifications of epoxides to create diverse libraries of inhibitors.