CAS: 72957-37-0; (S)-6-Amino-2-((S)-2-(2-Aminoacetamido)-3-(1H-Imidazol-4-yl)Propanamido)Hexanoic Acid Acetic Acid Salt

专利信息

专利号:US-4609622-A
优先权日:1983-05-31
标 题:Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line, FRTL-5
发明人：KOHN LEONARD D; VALENTE WILLIAM A; GROLLMAN-WOLFF EVELYN F; ALOJ SALVATORE M; VITTI PAOLO
权利人:INTERTHYR RESEARCH FOUNDATION; UNIV MARYLAND
摘要:A fast growing, continuous, functional rat thyroid cell strain, FRTL-5, which maintains functional characteristics of iodide uptake and thyroglobulin synthesis over prolonged periods of culture is cloned from FRTL cells obtained from primary cultures of Fischer rat thyroid glands. The FRTL-5 cells are cultured in a medium containing approximately 5 percent calf serum supplemented with a mixture of hormones, at least one of which is thyrotropin. n The FRTL-5 cells are employed in a series of assays which measure thyroid stimulatory or inhibitory factors. The FRTL-5 system of assay specifically measures thymidine incorporation, cAMP elevation and iodide uptake and permits the evaluation of patient sera, particularly those afflicted with Graves' disease and other autoimmune thyroid diseases, thereby providing a means for determining appropriate methods of treatment.

专利号:WO-2009044115-A1
优先权日:2007-09-29
标 题:Endocrine disruptors
发明人：WARING ROSEMARY HOPE; RAMSDEN DAVID BOYER
权利人:UNIV BIRMINGHAM; WARING ROSEMARY HOPE; RAMSDEN DAVID BOYER
摘要:A method is provided for assessing the potential of one or more test compounds to disrupt the endocrine system. The method comprises measuring the effect of the test compound(s) on hormone sulphation, oestrogen synthesis, and thyroid hormone and/or growth hormone function. These tests may be carried out sequentially or in parallel. Also provided is a test kit for assessing the endocrine disruption potential of a compound. The kit comprises means for assessing the effect of a compound on hormone sulphation, oestrogen synthesis, and thyroid hormone and/or growth hormone function. The kit may also contain comprise one or more optional control test compounds.

专利号:US-4608341-A
优先权日:1983-05-31
标 题:Living, fast-growing thyroid cell strain, FRTL-5
发明人：AMBESI-IMPIOMBATO FRANCESCO S
权利人:INTERTHYR RESEARCH FOUNDATION
摘要:A fast growing, continuous, functional rat thyroid cell strain, FRTL-5, which maintains functional characteristics of iodide uptake and thyroglobulin synthesis over prolonged periods of culture is cloned from FRTL cells obtained from primary cultures of Fischer rat thyroid glands. The FRTL-5 cells are cultured in a medium containing approximately 5 percent calf serum supplemented with a mixture of hormones, at least one of which is thyrotropin. The FRTL-5 cells are employed in a series of assays which measure thyroid stimulatory or inhibitory factors. The FRTL-5 system of assay specifically measures thymidine incorporation, cAMP elevation and iodide uptake and permits the evaluation of patient sera, particularly those afflicted with Graves' disease and other autoimmune thyroid diseases, thereby providing a means for determining appropriate methods of treatment.