CAS: 906673-24-3; 4-((1-Hydroxy-1,3-Dihydrobenzo[c][1,2]Oxaborol-5-yl)Oxy)Benzonitrile

上下游产品

Crisaborole Methyl Ester
1,3-二氢-2,1-苯并恶唑-1,5-二醇 Benzo[c][1,2]Oxaborole-1,5(3H)-Diol 1187190-70-0
4-(4-Cyanophenoxy)-2-Methylphenylboronic Acid 947162-07-4
4-(4-Cyanophenoxy)-2-Formylbenzeneboronic Acid 2247957-30-6
4-(Methoxy)-2-(Methoxymethyl)Benzeneboronic Acid
克立硼罗杂质5 4-(3-Formyl-4-(4,4,5 ,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenoxy)Benzonitrile 2141947-89-7

3-羟基苯甲酸乙酯置于aluminum (Iii) Chloride,Sodium Tetrahydroborate,N-溴代丁二酰亚胺(Nbs),正丁基锂,2,2,6,6-四甲基-3,5-庚二酮,Sodium Hydride,Caesium Carbonate,Copper(L) Chloride体系中,用 四氢呋喃,N-甲基吡咯烷酮,乙腈 作为反应溶剂,化学反应 31.0H,反应生成 4-[(1,3-二氢-1-羟基-2,1-苯并氧杂硼杂环戊烷-5-基)氧基]苯甲腈
参考文献:苯并硼唑类化合物的制备方法
标题:苯并硼唑类化合物的制备方法
摘要:本发明公开了一种苯并硼唑类化合物的制备方法,所述制备方法包括:(1)将含有卤代烃和硼酸酯的原料在碱性条件下反应,酸化水解得到中间体vi;(2)将含有中间体vi的原料与卤代苯腈反应,得到所述苯并硼唑类化合物.本发明的原料价格低,降低了苯并硼唑类化合物的制备成本,且制备过程无需有机基团的保护,脱保护步骤,简化了反应流程,避免因基团保护导致的产率降低;同时,本发明反应条件温和,对设备要求低,易于进行大规模工业生产.

专利信息

专利号:US-2025101045-A1
优先权日:2022-01-18
标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
发明人：DAS BHASKAR
权利人:LONG ISLAND UNIV
摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2023141114-A2
优先权日:2022-01-18
标 题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:AU-2020409711-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins