1-(2-Imino-5-Methyl-Oxazolidin-3-yl)-Propan-2-Ol置于氢氧化钾体系中,用 甲醇 用作溶剂,化学反应生成二异丙醇胺 参考文献:Kretov,A.E.; Matveev,I.S.,Journal Of General Chemistry Of The Ussr,1960,Vol. 30,# 9,P. 2998-3002 标题:Kretov,A.E.; Matveev,I.S.,Journal Of General Chemistry Of The Ussr,1960,Vol. 30,# 9,P. 2998-3002
专利号:US-8138330-B2 优先权日:2006-09-11 标 题 :Process for the synthesis of oligonucleotides 发明人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED 权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC 摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.
专利号:US-10167308-B2 优先权日:2013-09-14 标题:Highly efficient synthesis of long RNA using reverse direction approach 发明人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P 权利人:CHEMGENES CORP 摘要:The present invention relates to novel process of reverse 5′→3′ directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
专利号:US-2024400517-A1 优先权日:2022-02-08 标 题 :Chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline 发明人:ZHANG WANBIN; GAO FENG; LI JING; AHMAD TANVEER; ZHANG ZHENFENG; YUAN QIANJIA 权利人:UNIV SHANGHAI JIAOTONG 摘要:A chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, the chiral bimetallic cooperative catalysis system is formed by a metallic lithium, sodium or potassium salt and another metal salt under the action of a suitable ligand and an additive. By means of the chiral bimetallic cooperative catalysis system, an addition reaction of 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) is promoted, the selectivity is regulated, and a target product, (1R,2S)-bedaquiline, with high yield and high selectivity is obtained for the first time.
专利号:WO-2014059961-A1 优先权日:2012-10-15 标 题 :Method for the synchronous absorption of carbon dioxide from flue gas and synthesis of dialkyl carbonates and alkylene carbonates 发明人:BÜTTNER HERMANN; Müller Jürgen; JONKER RAPHAEL; DOEDT SEBASTIAN; BOSSE TOBIAS; MAKRAN SEBASTIAN 权利人:BÜTTNER HERMANN 摘要:The invention relates to a synchronous CCU method (carbon dioxide capture and utilisation) for the absorption of carbon dioxide from flue gas and other CO 2 -containing substance sources and simultaneous synthesis of dialkyl carbonates and alkylene carbonates. The general subject matter of the invention is, in terms of a 'carbon dioxide capture' on the one hand, the absorption of CO 2 from flue gas and other CO 2 -containing substance sources with ammonia and/or amines to form ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates and, in terms of a 'carbon dioxide utilisation' on the other hand, the reaction of ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates with aliphatic, alicyclic or unsaturated alcohols, and including unsaturated aromatic alcohols to give dialkyl carbonates or alkylene carbonates in such a form that the CO 2 n absorption agent is re-released and fed back into the repetitive process again. A repetitive process control is extremely energy and CO 2 n efficient.
专利号:US-5314674-A 优先权日:1991-11-08 标 题:Process for the synthesis of a zeolite of MTT type, products obtained and their application in adsorption and catalysts 发明人:DI R FRANCESCO DI RENZO; FRANCOIS FAJULA; THIERRY DES COURIERES; DIDIER ANGLEROT 权利人:ELF AQUITAINE 摘要:Process for the synthesis of a zeolite of MTT type in the absence of any nitrogenous organic agent, from a reaction mixture containing water, a source of tetravalent silicon and ethanol and optionally a source of trivalent aluminium and a source of hydroxide ions. The products obtained after heating the zeolite in air to 70 DEG -120 DEG C. or washing with water at 60 DEG -90 DEG C. are useful as selective organophilic adsorbents or as catalysts for the conversion of hydrocarbons.
专利号:US-8641790-B2 优先权日:2004-12-30 标题:Process for the synthesis of hydrocarbons from a carbonaceous fuel 发明人:ANSORGE JOACHIM; BILTON SCOTT; VAN DER PLOEG HENDRIK JAN; ROUTIER AROLD MARCEL ALBERT; SMIT CORNELIS JACOBUS 权利人:ANSORGE JOACHIM; BILTON SCOTT; VAN DER PLOEG HENDRIK JAN; ROUTIER AROLD MARCEL ALBERT; SMIT CORNELIS JACOBUS; SHELL OIL CO 摘要:A method of increasing the hydrogen/carbon monoxide (H 2 /CO) ratio in a syngas stream derived from a carbonaceous fuel including coal, brown coal, peat, and heavy residual oil fractions, preferably coal. The fuel-derived syngas stream is divided into at least two sub-streams, one of which undergoes a catalytic water shift conversion reaction. The so-obtained converted sub-stream is combined with the non-converted sub-stream(s) to form a second syngas stream with an increased H 2 /CO ratio. The method of the present invention can provide a syngas with a H 2 /CO ratio more suitable for efficient hydrocarbon synthesis carried out on a given catalyst, such as in one or more Fischer-Tropsch reactors, as well as being able to accommodate variation in the H 2 /CO ratio of syngas formed from different qualities of feedstock fuels.
摘要:Yoshida, H., Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis, (2019) 1, 69. 摘要:Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases., 30(7)(46), 1986 摘要:Ain Shams Medical Journal., 30(23), 1979 摘要:Bridie AL et al; Water Res 13 (7): 623-6 (1979) Available from, as of September 19, 2005 摘要:Prager, J.C. Environmental Contaminant Reference Databook Volume 2. New York, NY: Van Nostrand Reinhold, 1996., p. 824