CAS: 122-88-3; (4-Chlorophenoxy)Acetic Acid

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CAS号14426-42-7 4-氯苯氧乙酸乙酯 | CAS号106-48-9 对氯苯酚 | CAS号79-11-8 氯乙酸 | CAS号96-32-2 溴乙酸甲酯 | CAS号4841-22-9 2-(4-氯苯氧基)乙酸甲酯 | CAS号3926-62-3 氯乙酸钠 | CAS号94-75-7 2,4-二氯苯氧乙酸 | CAS号96-34-4 氯乙酸甲酯 | CAS号122-59-8 苯氧乙酸 | CAS号3685-84-5 盐酸甲氯芬酯 | CAS号106924-08-7 3-[[5-[(4-chlor... | CAS号106924-14-5 6,8-dibromo-3-[... | CAS号143999-83-1 2-(4-氯苯氧基)-1-哌嗪-1-乙酮 | CAS号51-68-3 氯酯醒 | CAS号4122-68-3 4-氯苯氧基乙酰氯 | CAS号3685-84-5 盐酸甲氯芬酯 | CAS号94-75-7 2,4-二氯苯氧乙酸 | CAS号18232-70-7 2-(4-chlorophen... | CAS号21086-49-7 2-(4-氯-2-硝基-苯氧基)乙酸 | CAS号124188-29-0 2-(4-chloro-2-n...

2-(4-氯苯氧)乙醇置于氧气,Molybdenum(Vi) Oxide体系中,用 水 用作溶剂,80.0 °C,100.0 Kpa 条件下,以187.16 G的收率获得对氯苯氧乙酸
参考文献:一种氯代苯氧羧酸的制备方法
标题:一种氯代苯氧羧酸的制备方法
摘要:本发明提供了一种氯代苯氧羧酸的制备方法,包括以下步骤:S1)苯氧脂肪醇在催化剂a和催化剂b的作用下,和氯化剂进行2位和/或4位的选择性氯化反应,得到氯代苯氧脂肪醇;所述催化剂a为路易斯酸;所述催化剂b为c5~22的硫醚,噻唑,异噻唑,噻吩或它们的卤代衍生物;S2)氯代苯氧脂肪醇和水,在催化剂的作用下,和氧化剂进行催化氧化反应,得到氯代苯氧羧酸.本发明通过对工艺路线的重新设计,对催化剂和氯化剂的精细筛选,有效降低了能耗,提高了氯化选择性同时避免了有效成分的损失,所得氯代苯氧羧酸的含量可达98.5%以上,总收率可达99%以上.

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.