CAS: 14484-47-0; Deflazacort

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CAS号16119-50-9 3β-hydroxy-2'-m... | CAS号13649-88-2 地夫可特 | CAS号13649-87-1 3β-acetoxy-11β-... | CAS号16119-56-5 21-hydroxy-2'-m... | CAS号13649-57-5 21-去乙酰基 地夫可特-d3

在 盐酸,水体系中,用 丙酮 用作溶剂,化学反应 24.0H,以72%的收率获得地夫可特
参考文献:Deflazacort 及其前体的快速合成和初步抗菌活性†
标题:Deflazacort 及其前体的快速合成和初步抗菌活性†
摘要:本文报道了 Deflazacort (Dfz) 的合成及其对人类病原体鲍曼不动杆菌和金黄色葡萄球菌的微生物活性的初步评估.虽然 Dfz 是无活性的,但其合成前体之一对革兰氏阴性和阳性细菌均显示出很强的抗菌活性.
Doi:10.1039/c9Ra03673C

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:WO-2024232849-A1
优先权日:2023-05-10
标 题:A pharmaceutical composition for increasing melanin synthesis in hair follicles
发明人：BALKAN GURSES NAZ DICLE; TULUNAY MAHIR
权利人:IFL PHARMA ILAC SANAYI VE TICARET ANONIM SIRKETI
摘要:The present invention relates to a pharmaceutical composition that is developed to convert white body hair, particularly hair, back to its original color. Particularly, the invention relates to a composition that works based on the increasing mechanism of melanin synthesis by regulating melanocyte cells. The pharmaceutical composition of the present invention is applied to the scalp via an intradermal method.