CAS: 150529-93-4; (R,R)-2,2-Isopropylidenebis(4-Phenyl-2-Oxazoline)

上下游产品

(S,S)-2,2'-methylenebis(4-phenyl-2-oxazoline) methyl iodide

N1,N3-双((R)-2-羟基-1-苯基乙基)-2,2-二甲基丙二酰胺置于polyethyleneglycol-Linked N-(Triethylammonium-Sulfonyl)Carbamate体系中,用 四氢呋喃,1,4-二氧六环 用作溶剂,化学反应 3.0H,以80%的收率获得(R,R)-2,2'-异亚丙基双(4-苯基-2-恶唑啉)
参考文献:Peg支撑的burgess试剂用于吡咯合成的改进方案
标题:Peg支撑的burgess试剂用于吡咯合成的改进方案
摘要:开发了与聚乙二醇连接的burgess试剂,并将其用于β-羟基酰胺和硫代酰胺的环脱水.以高收率和优异的纯度获得了所需的恶唑啉和噻唑啉.聚合物键合试剂的主要优点是其易处理性提高,并且在不稳定的恶唑啉的合成中产率大大提高.
Doi:10.1016/0040-4039(96)00918-5

专利信息

专利号:US-6680365-B1
优先权日:1998-03-19
标 题:Methods and compositions for controlled polypeptide synthesis
发明人：DEMING TIMOTHY J
权利人:UNIV CALIFORNIA
摘要:Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making block copolypeptides and related protocols for adding aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains by exposing the NCA to solutions containing polyaminoacid chains having an amido amidate metallacyle end groups and reacting the NCA with the amido containing metallacyle end group so that the NCA is added to the polyaminoacid chain. Addition methods include means of controlling the addition of aminoacid-N-carboxyanhydrides to polyaminoacid chains by reacting NCAs with initiator molecules and allowing initiator complexes to open the ring of the NCAs through oxidative addition across either the O—C 5 or O—C 2 anhydride bond resulting a controlled polypeptide polymerization. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

专利号:US-7173141-B2
优先权日:2005-03-09
标 题:Chiral lactones
发明人：ONISHI TOMOYUKI; WILLIAMS ROBERT M
权利人:AJINOMOTO KK
摘要:Lactones represented by the formula 2 a or 2 b : n nare provided, where each Ph is, independently, an unsubstituted or substituted phenyl group. These lactones are suitable for the synthesis of various α-hydroxy acids and 1,2-diols.