CAS: 367-32-8; 4-Fluorobenzene-1,2-Diol

上下游产品

4-fluoroveratrole 5-fluoro-2-methoxy phenol trifluoroacetic anhydride 5-fluoro-2-nitrophenol dimethyl 2,2'-((4-fluoro-1,2-phenylene)bis(oxy))diacetate 2,2'-(4-fluoro-1,2-phenylene)bisoxydiethanol 4-fluor°C atechol diacetate

4-氟苯酚置于尿素 盐酸,Oxy-Hemocyanine,三羟甲基氨基甲烷体系中,用 甲醇 作为反应溶剂,化学反应生成 4-氟-1,2-苯二酚
参考文献:尿素显着增强氧载体蛋白血蓝蛋白单加氧酶活性
标题:尿素显着增强氧载体蛋白血蓝蛋白单加氧酶活性
摘要:章鱼血蓝蛋白的 (Mu-Eta2:Eta2-Peroxo) 二铜 (II) 物种将一系列 P 取代酚氧化为相应的儿茶酚(酚酶活性),这是首次通过使用紫外可见光直接检测在厌氧条件下,在含有 8 M 尿素的 0.5 M 硼酸盐缓冲溶液中的光谱方法.初步动力学研究表明,该反应涉及亲电芳香取代机制,如酪氨酸酶的酚酶反应.当反应在有氧条件下进行时,血蓝蛋白对酚类的氧化也催化进行.
DOI:10.1021/ja061631H

专利信息

专利号:US-10597340-B2
优先权日:2013-05-10
标 题:Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination
发明人：SADEGHI SAMAN; HE QINGGANG; LEBEDEV ARTEM
权利人:UNIV CALIFORNIA
摘要:Provided herein are methods and compositions for the electrochemical selective radiofluorination of aromatic molecules. The resulting fluorine-18 labeled compounds are ideal radionuclides for use in Positron Emission Tomography (PET); they are also difficult to radiolabel efficiently and with high specific activity using existing approaches. For example, radiopharmaceuticals such as [F18]L-DOPA, which is indispensable in PET brain disease imaging, may be made electrochemically with high radiochemical yield and high specific activity using 18F-. The invention process described herein opens new possibilities and provides wider access to PET tracers such as 18F-L-Dopa, since 18F- is much more widely available than the 18F 2 , currently used for synthesis of electron rich substrates.

专利号:US-2016137567-A1
优先权日:2013-05-10
标题 :Synthesis of fluorinated radiopharmaceuticals via electrochemical fluorination