CAS: 368-54-7; 4-Hydroxy-6-(Trifluoromethyl)Pyrimidine-2-Thiol

相似化合物

16097-62-4 85730-33-2 78018-17-4

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CAS号372-31-6 三氟乙酰乙酸乙酯 | CAS号85730-32-1 2-(甲基磺酰基)-6-(三氟... | CAS号85730-36-5 2-氯-6-(三氟甲基)-4-氨基嘧啶 | CAS号672-45-7 6-(三氟甲基)尿嘧啶 | CAS号672-41-3 4-氨基-6-三氟甲基嘧啶 | CAS号1546-78-7 4-羟基-6-(三氟甲基)嘧啶 | CAS号16097-60-2 2-氨基-4-氯-6-三氟甲基嘧啶 | CAS号16097-62-4 6-三氟甲基-4-羟基-2-甲硫基嘧啶 | CAS号16097-63-5 4-氯-2-甲硫基-6-三氟甲基嘧啶 | CAS号16097-64-6 2,4-二氯-6-三氟甲基嘧啶 | CAS号836-12-4 [[1,4-二氢-4-氧代-6...

三氟乙酰乙酸乙酯置于sodium Methylate,硫脲体系中,用 甲醇,乙醇,水 作为反应溶剂,化学反应生成 4-羟基-6-(三氟甲基)嘧啶-2-硫醇
参考文献:Alpha-Substituted Pyrimidine-Thioalkyl And Alkylether Compounds As
标题:Alpha-Substituted Pyrimidine-Thioalkyl And Alkylether Compounds As
摘要:该发明涉及式(I)的嘧啶-硫代烷基和烷基醚化合物,以及式(Ia)的嘧啶-硫代烷基和烷基醚化合物,即式(I)中r.Sub.4选自--H或--Nr.Sub.15 R.Sub.16组,其中r.Sub.15为--H且r.Sub.16为--H,C.Sub.1-C.Sub.6烷基,Nh.Sub.2或r.Sub.15和r.Sub.16连同--N形成1-吡咯烷基,1-吗啉基或1-哌啶基;以及r.Sub.6选自--H或卤素(优选--Cl)的化合物组,总的限制条件是r.Sub.4和r.Sub.6不能同时为--H.式(Ia)的化合物在治疗hiv阳性个体中具有抑制病毒逆转录酶的作用.

专利信息

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5Dâ€?). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.