CAS: 557-66-4; Ethylamine Hydrochloride

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CAS号79-24-3 硝基乙烷 | CAS号85231-90-9 tert-butyl (die... | CAS号75-05-8 乙腈 | CAS号2576-47-8 2-溴乙胺氢溴酸盐 | CAS号90-05-1 愈创木酚 | CAS号2477-39-6 Ethylbis(trimet... | CAS号7370-34-5 N-Tritylethanamine | CAS号6402-60-4 2-(4-chlorophen... | CAS号35968-61-7 [nickel(II)bis(... | CAS号5470-11-1 盐酸羟胺 | CAS号10574-66-0 3-乙基-2-硫代-4-噁唑烷酮 | CAS号5339-67-3 N-Ethyl benzene... | CAS号35968-61-7 [nickel(II)bis(... | CAS号3858-78-4 正丁胺盐酸盐 | CAS号3081-61-6 L-茶氨酸 | CAS号945623-40-5 monosodium glutamate | CAS号4810-40-6 N-乙基砒啶-3-磺酰胺 | CAS号41882-25-1 N-乙基-4-溴苯甲酰胺 | CAS号90390-12-8 N-乙基-4-三氟甲基苄胺 | CAS号3846-50-2 2,4-二硝基-N-乙基苯胺

硝基乙烷置于甲酸,镍,盐酸体系中,用 甲醇 作为反应溶剂,化学反应 0.17H,以50%的收率获得产物乙胺盐酸盐
参考文献:镍催化的甲酸还原.减少硝基化合物的选择性方法
标题:镍催化的甲酸还原.减少硝基化合物的选择性方法
摘要:摘要 使用甲酸和雷尼镍以非常好的收率将脂肪族和芳香族硝基化合物选择性还原为其相应的氨基衍生物.发现该系统与多种敏感官能团兼容,例如卤素,-Oh,-och3,-Cho,-Coch3,-Coc6H5,-Cooh,-Cooc2H5,-Conh2,-Cn,-Ch=ch-Cooh,-Nhcoch3.不仅可以用 Hcooh 还可以用 Hcoonh4 进行还原.
DOI:10.1080/00397910008087439

专利信息

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:EP-0062322-A1
优先权日:1981-04-03
标 题 :Improved process for synthesis of hindered amine stabilizers for polymeric materials
发明人：LAI JOHN TA-YUAN
权利人:GOODRICH CO B F
摘要:Process for the synthesis of hindered polysubstituted α-amino acetamides by reaction of a secondary amine with an α-halo acetamide in a basic organic reaction medium and in the presence of a phase transfer catalyst. The product thus obtained can comprise a multifunctional compound having one or more hindered amino moieties. These compounds are highly effective as UV stabilizers in a variety of plastics, especially the alpha monoolefins.

专利号:US-12251674-B2
优先权日:2012-11-14
标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis
发明人：RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA
权利人:VIBRANT HOLDINGS LLC
摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

专利号:WO-2024134682-A1
优先权日:2022-12-21
标题:(n-alkyldihydrol-2h-oxazinyl)-cannabidiol as anti-proliferative agent and process for preparation thereof
发明人：CHAM PANKAJ SINGH; SINGH AJEET; JAMWAL ASHIYA; SINGH RATTANDEEP; - SHABU; THAPA SONIA; WAZIR PRIYA; NANDI UTPAL; SINGH SHASHANK KUMAR; SINGH PARVINDER PAL
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
摘要:The present invention relates to ring annulated analogues of cannabidiol where either one or both sides of the aromatic ring are attached to the oxazinyl ring, their method of preparation and use as anti-proliferative agents. The present invention provides a ring annulated cannabidiol analogue compound of Formula I. The present invention further provides a process for the synthesis of ring annulated cannabidiol analogue compound of Formula I.

专利号:US-7154005-B2
优先权日:2004-09-09
标 题:Synthesis of alpha fluoroalkyl amines
发明人：O'SHEA PAUL; GOSSELIN FRANCIS
权利人:MERCK FROSST CANADA LTD
摘要:This invention describes the reaction of an alpha fluoroalkyl ketone with a bis(trialkylsilyl)amide to give a stable N-trialkylsilyl imine. Treatment of the N-trialkylsilyl imine with an alcohol leads to solvolysis of the trialkylsilyl group and yields a stable mixture of an aminal and an imine in high yield. Catalytic reduction of this mixture, or of the individual components, in the presence of a chiral catalyst leads to a fluoroalkyl amine with high enantioselectivity and high yield.

专利号:US-11420997-B2
优先权日:2018-04-13
标题:Peptide synthesis method
发明人：SUZUKI HIDEAKI; MUTO SUSUMU; FUJITA SHUJI; KUBO DAISUKE
权利人:JITSUBO CO LTD
摘要:The present invention has an object of shortening the process time and reducing use of a poor solvent for solidifying a carrier (Tag)-peptide component, by removing impurities without conducting solid-liquid separation (condensation, solid-liquid separation and drying operation) of a Tag-peptide component, in an Fmoc method using a Tag for liquid phase peptide synthesis. Provided is the peptide synthesis method that includes the following steps a-d: step a: a carrier-protected amino acid, carrier-protected peptide, or a carrier-protected amino acid amide, and an N-Fmoc-protected amino acid or an N-Fmoc-protected peptide are condensed in an organic solvent or a mixed solution of organic solvents, to obtain an N-Fmoc-carrier-protected peptide, step b: a water-soluble amine is added to the reaction solution after the condensation reaction, step c: the Fmoc group is deprotected from the protected amino group in the presence of a water-soluble amine, and step d: the reaction solution is neutralized by adding an acid, and further, by adding and washing with an acidic aqueous solution, then, by liquid-liquid separation an aqueous layer is removed to obtain an organic layer.