CAS: 604-59-1; 2-Phenyl-4H-Benzo[h]Chromen-4-One

上下游产品

CAS号65-85-0 苯甲酸

1-羟基-2-奈甲醛置于4-二甲氨基吡啶,Manganese(Iv) Oxide,正丁基锂体系中,用 四氢呋喃,正己烷,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 28.5H,反应生成 α-萘黄酮
参考文献:通过dmap催化邻炔基苯酚的环化区域选择性合成黄酮衍生物
标题:通过dmap催化邻炔基苯酚的环化区域选择性合成黄酮衍生物
摘要:Dmap催化量的促进环化ö-Alkynoylphenols经由6-内环化模式,导致高产量黄酮衍生物,而不形成5-外型环化噢哢衍生物.利用这种方法,合成了甲氧基取代的黄酮和烷基取代的γ-苯并吡喃酮衍生物.
DOI:10.1016/j.Tet.2011.09.063

专利信息

专利号:US-2021284618-A1
优先权日:2016-08-12
标 题 :Furanochalcones as inhibitors of cyp1a1, cyp1a2 and cyp1b1 for cancer chemoprevention
发明人：BHARATE SANDIP BIBISHAN; SHARMA RAJNI; JOSHI PRASHANT; VISHWAKARMA RAM; CHAUDHURI BHABATOSH
权利人:COUNCIL SCIENT IND RES; DE MONTFORT UNIV
摘要:The present invention relates to the furanochalcone class of compounds of general formula A. The present invention particularly relates to the synthesis of furanochalcones and their CYP1A1, CYP1A2 and CYP1B1 inhibitory activity. In addition, the invention relates to the prevention or treatment of cancer caused by polyaromatic hydrocarbons (PAHs), 4-nitroquinoline-1-oxide, and N-nitroso-N-methylurea, heterocyclic amines, estrogen and 17β-estradiol, resulting from the inhibition of CYP1A1, CYP1A2 and CYP1B1 enzymes.

专利号:WO-2021038419-A1
优先权日:2019-08-23
标题 :Kinase inhibitors and methods of synthesis and treatment
发明人：ZAVORONKOVS ALEKSANDRS; IVANENKOV YAN; POLYKOVSKIY DANIIL; ALIPER ALEKSANDR
权利人:INSILICO MEDICINE IP LTD
摘要:Compounds that function as kinase inhibitors are provided. The kinase inhibitors can have any structure of the formulae provided herein, such as shown for Compounds 1-4. A pharmaceutical composition can include: the compound of one of the embodiments; and a pharmaceutically acceptable carrier having the compound. A method of inhibiting a kinase can include: providing the compound of one of the embodiments described herein to the kinase such that the kinase is inhibited. The methods can include inhibiting DDR1 and/or DDR2, and thereby providing a modulation or decrease in the activity of DDR1 and/or DDR2. This decrease in DDR1 and/or DDR2 activity can be used as therapy to treat conditions related to DDR1 and/or DDR2 activity, such as fibrosis, cancer, and others.

专利号:US-2013164265-A1
优先权日:2011-12-21
标题 :Skin care compositions
发明人：FLAVIN DANA; OBENLAND SIGRID
权利人:FLAVIN DANA; OBENLAND SIGRID
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-2014328952-A1
优先权日:2011-12-21
标题:Topical compositions
发明人：FLAVIN DANA
权利人:FLAVIN DANA
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-2023295141-A1
优先权日:2022-03-17
标 题:Fxr small molecule agonist, the preparation and use thereof
发明人：ZHAO YISHUANG; ZHANG ZHENWEI; WU GUOHUI; YANG SHENGSHENG
权利人:CASCADE PHARMACEUTICALS INC
摘要:The present invention discloses an FXR (farnesoid X receptor) small molecule agonist, the structure of which is shown in formula I, and a preparation method thereof. In the formula, the definition of each substituent is as described in the specification and claims. The compound of the present invention has advantages, such as high FXR agonistic activity, convenience in synthesis, easy availability of raw materials, and can be used as a medicine for the treatment of FXR-related diseases.

专利号:US-10829464-B2
优先权日:2016-11-23
标题 :Benzoheterocyclic alkylamine compounds and use thereof
发明人：LI JIAN; LAN LEFU; LI BAOLI; CHEN FEIFEI; NI SHUAISHUAI; LIU YIFU; WEI HANWEN; MAO FEI; ZHU JIN
权利人:UNIV EAST CHINA SCIENCE & TECH; SHANGHAI INST MATERIA MEDICA CAS
摘要:Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus .