CAS: 65864-64-4; (Difluoromethyl)Trimethylsilane

相似化合物

81290-20-2 115262-01-6 115262-00-5

上下游产品

CAS号75-77-4 三甲基氯硅烷 | CAS号1535-65-5 二氟甲基苯基砜 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号115262-00-5 (氯二氟甲基)三甲基硅烷 | CAS号115262-01-6 (溴二氟甲基)三甲基硅烷 | CAS号75-76-3 四甲基硅烷 | CAS号115262-01-6 (溴二氟甲基)三甲基硅烷 | CAS号915799-67-6 1-(苄氧基)-4-(二氟甲基)苯

四甲基硅烷置于fluorine体系中,化学反应 168.0H,反应生成 (二氟甲基)三甲基硅烷
参考文献:二甲基汞,四甲基硅烷和四甲基锗的氟化.多氟四甲基硅烷,多氟四甲基锗,双(三氟甲基)汞和四(三氟甲基)锗的合成与表征
标题:二甲基汞,四甲基硅烷和四甲基锗的氟化.多氟四甲基硅烷,多氟四甲基锗,双(三氟甲基)汞和四(三氟甲基)锗的合成与表征
摘要:已经发现可以在直接氟化过程中保留金属(碳和准金属)的碳键.二甲基汞与氟的反应以6.5%的收率得到双(三氟甲基)汞.四甲基硅烷的氟化作用导致分离出以下类型的新型多氟四甲基硅烷:Si(ch 3)x(ch 2 F)y(chf 2)z,X + Y + Z = 4. Cf 3.通过氟与四甲基锗的反应,有可能以63.5%的产率合成四(三氟甲基)锗.还表征了以下类型的许多多氟四甲基锗烷,Ge(cf 3)x(cf 2 H)y(cfh 2)z(x + Y + Z = 4).
DOI:10.1016/s0022-328X(00)91121-5

专利信息

专利号:US-2022056025-A1
优先权日:2018-09-25
标 题:Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones
发明人：BROWN ADAM ROSS; DESROSIERS JEAN-NICOLAS; DUAN SHENGQUAN; HAWKINS JOEL MICHAEL; HAYWARD CHERYL MYERS; MALONEY MARK THOMAS; MONFETTE SEBASTIEN; PERFECT HAHDI HAKIMIOUN; WIDLICKA DANIEL WILLIAM
权利人:PFIZER
摘要:This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.

专利号:US-9475756-B2
优先权日:2012-03-05
标题:Difluoromethylation of aryl and vinyl iodides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:Selectively fluorinated molecules are important as materials, pharmaceuticals, and agrochemicals, but their synthesis by simple, mild, laboratory methods is challenging. We report a straightforward method for the cross-coupling of a difluoromethyl group with readily available reagents to form difluoromethylarenes. The reaction of electron-neutral, electron rich, and sterically hindered aryl and vinyl iodides with the combination of CuI, CsF and TMSCF 2 H leads to the formation of difluoromethylarenes in high yield with good functional group compatibility. This transformation is surprising, in part, because of the prior observation of the instability of CuCF 2 H.

专利号:WO-2020065494-A1
优先权日:2018-09-25
标 题 :Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones

专利号:CA-3113832-A1
优先权日:2018-09-25
标题:Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones

专利号:JP-WO2020032152-A1
优先权日:2018-08-09
标题 :Stereoselective synthesis of 4'-substituted nucleoside derivatives

专利号:EP-3856725-A1
优先权日:2018-09-25
标题 :Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones