专利号:US-12006540-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J 权利人:UNIV COLUMBIA 摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
专利号:US-7229785-B2 优先权日:2002-04-19 标 题 :Fluorescence technique for on-line monitoring of state of hydrogen-producing microorganisms 发明人:SEIBERT MICHAEL; MAKAROVA VALERIYA; TSYGANKOV ANATOLY A; RUBIN ANDREW B 权利人:MIDWEST RESEARCH INST 摘要:In situ fluorescence method to monitor state of sulfur-deprived algal culture's ability to produce H 2 under sulfur depletion, comprising: a) providing sulfur-deprived algal culture; b) illuminating culture; c) measuring onset of H 2 percentage in produced gas phase at multiple times to ascertain point immediately after anerobiosis to obtain H 2 data as function of time; and d) determining any abrupt change in three in situ fluorescence parameters; i) increase in F t (steady-state level of chlorophyll fluorescence in light adapted cells); ii) decrease in F m′ , (maximal saturating light induced fluorescence level in light adapted cells); and iii) decrease in ΔF/F m ′=(F m ′−F t )/F m ′ (calculated photochemical activity of photosystem II (PSII) signaling full reduction of plastoquinone pool between PSII and PSI, which indicates start of anaerobic conditions that induces synthesis of hydrogenase enzyme for subsequent H 2 production that signal oxidation of plastoquinone pool asmain factor to regulate H 2 under sulfur depletion.
专利号:WO-03088736-A1 优先权日:2002-04-19 标题 :Fluorescence technique for on-line monitoring of state of hydrogen-producing microorganisms 发明人:SEIBERT MICHAEL; MAKAROVA VALERIYA; TSYGANKOV ANATOLY A; RUBIN ANDREW B 权利人:MIDWEST RESEARCH INST; SEIBERT MICHAEL; MAKAROVA VALERIYA; TSYGANKOV ANATOLY A; RUBIN ANDREW B 摘要:In situ fluorescence method to monitor state of sulfur-deprived algal culture's ability to produce H2 under sulfur depletion, comprising: a) providing sulfur-deprived algal culture; b) illuminating culture; c) measuring onset of H2 percentage in produced gas phase at multiple times to ascertain point immediately after anerobiosis to obtain H2 data as function of time; and d) determining any abrupt change in three in situ fluorescence parameters; i) increase in Ft (steady-state level of chlorophyll fluorescence in light adapted cells); ii) decrease in Fm' (maximal saturating light induced fluorescence level in light adapted cells); and iii) decrease in Δ F/Fm' = (Fm'-Ft)/Fm' (calculated photochemical activity of photosystem II (PSII) signaling full reduction of plastoquinone pool between PSII and PSI, which indicates start of anaerobic conditions that induces synthesis of hydrogenase enzyme for subsequent H2 production that signal oxidation of plastoquinone pool asmain factor to regulate H2 under sulfur depletion.
专利号:US-11959137-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
专利号:US-2024376536-A1 优先权日:2015-09-28 标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis
专利号:US-2022411860-A1 优先权日:2015-09-28 标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis
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合成参考文献
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