CAS: 91-13-4; 1,2-Bis(Bromomethyl)Benzene

上下游产品

CAS号95-47-6 邻二甲苯 | CAS号612-14-6 邻苯二甲醇 | CAS号34904-98-8 [2-(苯氧基甲基)苯基]甲醇 | CAS号89-92-9 2-甲基苄基溴 | CAS号89-95-2 邻甲基苄醇 | CAS号168971-56-0 2-(苯氧基甲基)苄胺 | CAS号109179-39-7 ethyl 3-phenyls... | CAS号78808-36-3 1,2-bis(phenyls... | CAS号105961-94-2 1,2-bis(phenyls... | CAS号106020-70-6 2-(甲氧基甲基)苯甲醛 | CAS号496-14-0 二氢异苯并呋喃 | CAS号612-14-6 邻苯二甲醇 | CAS号33982-85-3 1-(2,3-二氢-1H-茚-... | CAS号496-12-8 异吲哚啉 | CAS号141120-17-4 2-氨基茚满-2-膦酸 | CAS号141738-19-4 Spiro[1,3-dioxa...

邻二甲苯置于n-溴代丁二酰亚胺(Nbs),1,1'-偶氮(氰基环己烷)体系中,用 三氟甲苯 作为反应溶剂,化学反应 4.0H,以54%的收率获得产物1,2-二(溴甲基)苯
参考文献:N-溴代琥珀酰亚胺在(三氟甲基)苯中的苄基溴化反应
标题:N-溴代琥珀酰亚胺在(三氟甲基)苯中的苄基溴化反应
摘要:在(2,2'-偶氮二异丁腈,1,1'-偶氮二(环己烷甲腈)或过氧化苯甲酰作为自由基引发剂的存在下,通过在(三氟甲基)苯中的n-溴琥珀酰亚胺在(三氟甲基)苯中进行光化学活化,进行了各种苄基溴化反应.该系统提供了清洁,快速和高产率的反应,并用毒性较小的三氟甲基苯代替了传统的溶剂,例如四氯甲烷. 苄基溴化-(三氟甲基)苯-自由基-N-溴代琥珀酰亚胺-偶氮二异丁腈
DOI:10.1055/s-0029-1216793

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6320058-B2
优先权日:2000-02-25
标题:Process for the preparation of isoindoline
发明人：SOUVIE JEAN-CLAUDE; FUGIER CLAUDE; LECOUVE JEAN-PIERRE
权利人:ADIR
摘要:Process for the industrial synthesis of isoindoline by catalytic hydrogenation of phthalonitrile, and its application in the synthesis of 2-(S)-benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)-butyric acid, its pharmaceutically acceptable salts and its hydrates.

专利号:US-5856492-A
优先权日:1997-01-10
标题 :Efficient synthesis of a chiral mediator
发明人：CHEN CHENG YI; XU FENG; TILLYER RICHARD D; ZHAO DALIAN
权利人:MERCK & CO INC
摘要:An efficient method for the quantitative preparation and isolation of a compound of formula I ##STR1## or its enantiomer, a chiral mediator used in enantioselective synthesis.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.