CAS: 10433-52-0; H-D-Ser(Bzl)-Oh

相似化合物

1233494-98-8 4726-96-9 5445-44-3

上下游产品

CAS号5445-44-3 O-苄基-DL-丝氨酸 | CAS号3587-60-8 苄基氯甲基醚 | CAS号1233494-98-8 (R)-2-氨基-3-(苄氧基... | CAS号84907-81-3 HN2-Ser(Bn)-OMe | CAS号84907-79-9 (3R,6S)-3-Benzy... | CAS号84907-80-2 (3S,6R)-6-Benzy... | CAS号47173-80-8 N-B°C-O-苄基-D-丝氨酸 | CAS号79069-15-1 N-B°C-(S)-2-氨基-... | CAS号58577-88-1 (S)-(-)-2-氨基-3-...

N-Boc-O-苄基-D-丝氨酸置于盐酸体系中,用 1,4-二氧六环 用作溶剂,以32%的收率获得o-苄基-D-丝氨酸
参考文献:Nmda受体甘氨酸结合位点的亚型特异性激动剂
标题:Nmda受体甘氨酸结合位点的亚型特异性激动剂
摘要:设计了一系列基于丝氨酸为先导结构的类似物,并使用两电极电压钳(tevc)电生理学对重组nmda受体亚型(glun1 / 2A-D)的激动剂活性进行了评估.以依赖于nmda受体中的glun2亚基的方式观测到亚基选择性,效力和激动剂功效的明显变化.特别是化合物15A和16A是在glun1亚基上有效的glun2C特异性超激动剂,与甘氨酸相比,激动剂的效率为398%和308%.这项研究表明,可以实现甘氨酸位点nmda受体激动剂之间的亚基选择性,并建议可以开发出甘氨酸位点的激动剂作为药理工具化合物,以研究nmda受体介导的神经传递中glun2C的特异性作用.
Doi:10.1021/acschemneuro.7B00117

专利信息

专利号:US-2003180804-A1
优先权日:2001-10-29
标题:Solid phase synthesis of chemical libraries
发明人：PRYOR KENT E; LEWIS RONALD D; BROWN JASON W
权利人:CORVAS INT INC
摘要:The present invention provides compounds and compound libraries that are useful as protease modulators. The compounds and compound libraries are preferably made using the methods of the present invention which utilize peptide synthesis and combinatorial chemistry methods on a solid phase.

专利号:US-6867202-B1
优先权日:1997-06-25
标 题 :Treatment of insulin resistance
发明人：CARPINO PHILIP ALBERT; CHIU CHARLES KWOK-FUNG; PAN LYDIA CODETTA; LEFKER BRUCE ALLEN; TREADWAY JUDITH LEE; ZAWISTOSKI MICHAEL PAUL
权利人:PFIZER
摘要:This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, n n nwhere the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-4089821-A
优先权日:1976-03-31
标 题:Synthesis of peptide amides
发明人：ENKOJI TAKASHI; SKIBBE MARTIN O
权利人:ARMOUR PHARMA
摘要:Peptide amides having biological activity and resin peptide amides useful in the preparation of peptides having biological activity, particularly such peptides containing the structure in which R is divinylbenzene crosslinked polystyrene and Bz is benzyl, p-methoxybenzyl, p-chlorobenzyl, p-nitrobenzyl, or benzhydryl, and in which phe and glu are residues of the amino acids phenylalanine and glutamic acid; and processes for preparing such peptide amides.

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries